Results 141 to 150 of about 76,644 (252)

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins   +8 more
wiley   +1 more source

Customizing AI‐based screening with real‐world data: Practical insights from diabetic retinopathy

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page 323-332, May 2026.
Abstract Purpose Diabetic retinopathy (DR) is a leading cause of vision loss in middle‐aged adults globally. Although artificial intelligence (AI)‐based screening tools like IDx‐DR (classification) and Thirona RetCAD (regression) have shown high sensitivity in controlled settings, real‐world screening faces challenges due to missing or low‐quality ...
Broder Poschkamp   +17 more
wiley   +1 more source

Characterising PRPF31‐associated retinal dystrophy: Clinical insights from baseline data in a natural history study

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page e317-e328, May 2026.
Abstract Purpose To characterise the baseline clinical features and genotypes of adults with pre‐mRNA processing factor 31 (PRPF31)‐associated retinal dystrophy (RD) enrolled in a prospective, multicentre 4‐year natural history study, and to explore correlations between selected baseline parameters.
Kathrine Olaussen Eriksen   +6 more
wiley   +1 more source

Triamcinolona subtenoniana en el edema macular diabético Subtenon triamcinolone in the diabetic macular edema

open access: yesRevista Cubana de Oftalmología, 2009
INTRODUCCIÓN: La prevalencia de la retinopatía diabética está determinada por el tipo de diabetes mellitus y por el tiempo de evolución de la enfermedad.
Eddy Mesa Hernández   +4 more
doaj  

Neovascular age‐related macular degeneration without drusen

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page e300-e311, May 2026.
Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks   +9 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

Visual improvement after long-term success of pancreatic transplantation [PDF]

open access: yes, 1990
Andreas G. Tzakis   +6 more
core   +1 more source

Cost‐utility of once‐weekly insulin icodec versus once‐daily basal insulins for type 2 diabetes in China

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3872-3882, May 2026.
Abstract Objective To comprehensively assess the cost‐utility of icodec, the first once‐weekly basal insulin, at 700 and 1050 U formulations compared with once‐daily basal insulin analogues in Chinese adults with type 2 diabetes within reimbursement context.
Xichen Tong   +3 more
wiley   +1 more source

Ranibizumab in the treatment of patients with visual impairment due to diabetic macular edema

open access: yesClinical Ophthalmology, 2011
Francesco Bandello1, Umberto De Benedetto1, Karl Anders Knutsson1, Maurizio Battaglia Parodi1, Maria Lucia Cascavilla1, Pierluigi Iacono21Department of Ophthalmology, University Vita-salute, Scientific Institute San Raffaele, Milan, Italy; 2Fondazione G ...
Bandello F   +5 more
doaj  

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