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Spectrophotometric Titration of Edetic Acid in Ophthalmic Solutions
Journal of Pharmaceutical Sciences, 1974The procedure described here is applicable for determining edetic acid (ethylenediaminetetraacetic acid) at the 0.05–0.2% level in ophthalmic solutions. This method employs a spectrophotometric titration, using a magnesium-ion solution as titrant and arsenazo I as the indicator.
E E, Kaminski, D M, Pacenti
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SYNERGISTIC EFFECT OF EDETIC-ACID/ANTIBIOTIC COMBINATIONS ON PSEUDOMONAS ÆRUGINOSA
Lancet, The, 1969Abstract The disodium salt of ethylenediamine-tetra-acetic acid (E.D.T.A., edetic) enhances the effect of penicillin G, ampicillin, tetracycline, and chloramphenicol on a resistant strain of Pseudomonas œruginosa. This effect is shown to be due to synergism of the E.D.T.A./antibiotic combinations.
A W Asscher
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The control of nitrilotriacetic acid in edetic acid and its salts by liquid chromatography
Journal of Pharmaceutical and Biomedical Analysis, 2003Two liquid chromatographic methods have been developed and validated for the determination of nitrilotriacetic acid (NTA) in edetic acid (EDTA) and its salts. In one method NTA and EDTA are separated on a polymer column without pretreatment, and are detected amperometrically using a glassy-carbon electrode.
G G Skellern
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Lancet, The, 1968
Abstract One hundred and forty-seven simultaneous inulin and 51 Cr-labelled edetic acid (E.D.T.A.) clearances have been performed in thirty-nine patients. Compared with inulin, 51 Cr-E.D.T.A. significantly underestimates the glomerular filtration-rate, and it cannot yet be considered a suitable alternative to inulin for precise measurement of ...
D A, Heath, M S, Knapp, W H, Walker
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Abstract One hundred and forty-seven simultaneous inulin and 51 Cr-labelled edetic acid (E.D.T.A.) clearances have been performed in thirty-nine patients. Compared with inulin, 51 Cr-E.D.T.A. significantly underestimates the glomerular filtration-rate, and it cannot yet be considered a suitable alternative to inulin for precise measurement of ...
D A, Heath, M S, Knapp, W H, Walker
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MEASUREMENT OF GLOMERULAR FILTRATION-RATE IN MAN USING A 51Cr/EDETIC-ACID COMPLEX
Lancet, The, 1967Abstract 51 Cr complexed with edetic acid ( 51 Cr-E.D.T.A.) can be prepared in a form which is stable when autoclaved and in vivo. It does not bind to protein or enter red blood-cells and excretion via the gut is insignificant. The renal clearance, as measured by the continuous-infusion technique, is the same as that of inulin.
V Parsons, E S Garnett
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Drug Transfer across Rat Intestinal Musculature after Edetic Acid Treatment
Journal of Pharmaceutical Sciences, 1971The columnar epithelium of the in vitro rat intestine was separated from the intestinal musculature by treatment with icecold edetic acid solution. The in vitro absorption kinetics through the denuded intestinal musculature for salicylate ion and acetanilide were followed in pH 7.4 sodium phosphate and potassium phosphate buffers, as well as in an ...
Leslie Z Benet, L Z Benet
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EDETIC-ACID TEST OF PARATHYROID INSUFFICIENCY
Lancet, The, 1963P Fourman, Paul Fourman
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Light Scattering Changes of Edetic Acid-Treated, Washed Rat Platelets
Thrombosis and Haemostasis, 1975SummaryThe effects of adenosine diphosphate (ADP) and Ca2+ on platelet morphology were studied in edetic acid (EDTA)-treated, washed platelets of rat by means of light scattering measurement at right angles. ADP caused a transient change of light scattering, which was independent of concentration above 5 μM and of pH between 4 and 10.
Bonro Kobayashi
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Journal of Infectious Diseases, 1973
A rat-burn model was used for the evaluation of combinations of edetic acid and antibiotics in the treatment of thermal burns infected with a strain of Pseudomonas aeruginosa resistant to ampicillin and tetracycline. Experiments were standardized so that a fixed inoculum size of the test organism produced 100% mortality in two weeks when applied to a ...
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A rat-burn model was used for the evaluation of combinations of edetic acid and antibiotics in the treatment of thermal burns infected with a strain of Pseudomonas aeruginosa resistant to ampicillin and tetracycline. Experiments were standardized so that a fixed inoculum size of the test organism produced 100% mortality in two weeks when applied to a ...
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