Results 91 to 100 of about 9,430 (262)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cartesian积与邻点可区别着色之间的关系(Relation between Cartesian product and adjacent vertex distinguishing coloring)

Zhejiang Daxue xuebao. Lixue ban, 2017
A proper k-edge coloring of a graph G is an assignment of k colors 1, 2, …, k to edges of G such that any two adjacent edges receive the different colors.
WANGGuoxing(王国兴)
doaj   +1 more source

Parsimonious edge-coloring on surfaces

Electronic Journal of Graph Theory and Applications, 2018
We correct a small error in a 1996 paper of Albertson and Haas, and extend their lower bound for the fraction of properly colorable edges of planar subcubic graphs that are simple, connected, bridgeless, and edge-maximal to other surface embeddings of ...
Sarah-Marie Belcastro
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

IMPLEMENTASI ALGORITMA GREEDY UNTUK MELAKUKAN GRAPH COLORING: STUDI KASUS PETA PROPINSI JAWA TIMUR

Jurnal Informatika, 2010
This paper will describe us how to coloring a graph by using greedy algorithm with the case study province of Jawa Timur. From this research we will know that for graph coloring at Jawa Timur Province only use four difference colors.
Ardiansyah Ardiansyah, Fery Sofian Efendi, Syaifullah Syaifullah, Mateus Pinto, Pujianto Pujianto, Hendro Steven Tempake   +5 more
doaj   +1 more source

On Orthogonal Vector Edge Coloring

CoRR, 2019
Given a graph $G$ and a positive integer $d$, an orthogonal vector $d$-coloring of $G$ is an assignment $f$ of vectors of $\mathbb{R}^d$ to $V(G)$ in such a way that adjacent vertices receive orthogonal vectors. The orthogonal chromatic number of $G$, denoted by $χ_v(G)$, is the minimum $d$ for which $G$ admits an orthogonal vector $d$-coloring.
Ana Silva 0001, Allen Ibiapina
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source