Results 61 to 70 of about 2,800 (259)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

On (k1A1, k2A2, k3A3)-Edge Colourings in Graphs and Generalized Jacobsthal Numbers

Annales Mathematicae Silesianae
In this paper we introduce a new kind of generalized Jacobsthal numbers in a distance sense. We give the identities and matrix representations for them and their connections with the Fibonacci and the Pell numbers. We also describe the interpretations of
Piejko Krzysztof, Trojnar-Spelina Lucyna
doaj   +1 more source

The power of many colours

Forum of Mathematics, Sigma
A classical problem, due to Gerencsér and Gyárfás from 1967, asks how large a monochromatic connected component can we guarantee in any r-edge colouring of $K_n$ ?
Noga Alon, Matija Bucić, Micha Christoph, Michael Krivelevich   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Oriented Incidence Colourings of Digraphs

Discussiones Mathematicae Graph Theory, 2019
Brualdi and Quinn Massey [6] defined incidence colouring while study- ing the strong edge chromatic index of bipartite graphs. Here we introduce a similar concept for digraphs and define the oriented incidence chromatic number.
Duffy Christopher, MacGillivray Gary, Ochem Pascal, Raspaud André   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

On the Palette Index of Complete Bipartite Graphs

Discussiones Mathematicae Graph Theory, 2018
The palette of a vertex x of a graph G determined by a proper edge colouring φ of G is the set {φ(xy) : xy ∈ E(G)} and the diversity of φ is the number of different palettes determined by φ. The palette index of G is the minimum of diversities of φ taken
Horňák Mirko, Hudák Juraj
doaj   +1 more source