Results 131 to 140 of about 4,425 (218)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Safety Assessment of Rehabilitation Robots: A Review Identifying Safety Skills and Current Knowledge Gaps. [PDF]

Front Robot AI, 2021
Bessler J, Prange-Lasonder GB, Schaake L, Saenz JF, Bidard C, Fassi I, Valori M, Lassen AB, Buurke JH.   +8 more
europepmc   +1 more source

Financial Statement Information and Equity Value: The Role of Real Options Characteristics

Financial Management, EarlyView.
ABSTRACT This paper examines whether firm‐specific real options characteristics are equity value‐relevant beyond valuation estimates anchored in financial statements. Using extensive historical data for the United Kingdom, we assess and compare the forecast accuracy and explanatory power for stock prices of equity valuation models based on residual ...
Mingyu (Chandler) Chen, Colin Clubb, Tarik Driouchi   +2 more
wiley   +1 more source

Foundational Considerations for Artificial Intelligence Using Ophthalmic Images. [PDF]

Ophthalmology, 2022
Abràmoff MD, Cunningham B, Patel B, Eydelman MB, Leng T, Sakamoto T, Blodi B, Grenon SM, Wolf RM, Manrai AK, Ko JM, Chiang MF, Char D, Collaborative Community on Ophthalmic Imaging Executive Committee and Foundational Principles of Ophthalmic Imaging and Algorithmic Interpretation Working Group.   +13 more
europepmc   +1 more source

On \(k\)-graceful labeling of pendant edge extension of complete bipartite graphs [PDF]

, 2018
Soumya Bhoumik, Sarbari Mitra
openalex  

Strong k - edge odd Graceful labeling of graphs

, 2018
Mohamed R. Zeen El Deen
openalex   +1 more source

Theological Doctrines as Scientific Theories? Thinking along with and beyond McGrath

International Journal of Systematic Theology, EarlyView.
Abstract McGrath's recent analysis of the parallels between scientific theory formation and the development of theological doctrine in The Nature of Christian Doctrine (OUP, 2024) is insightful and largely compelling, but also raises some questions and areas for further exploration. First, there is a remarkable back‐and‐forth between uses of ‘doctrine’
Gijsbert van den Brink
wiley   +1 more source

AdaptPest-Net: A Task-Adaptive Network with Graph-Mamba Fusion for Multi-Scale Agricultural Pest Recognition. [PDF]

Entropy (Basel)
Zou J, Yang W, Li C, Feng Z.
europepmc   +1 more source

Tai Chi Training Evokes Significant Changes in Brain White Matter Network in Older Women. [PDF]

Healthcare (Basel), 2020
Yue C, Zou L, Mei J, Moore D, Herold F, Müller P, Yu Q, Liu Y, Lin J, Tao Y, Loprinzi P, Zhang Z.   +11 more
europepmc   +1 more source