Results 61 to 70 of about 898,897 (299)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

A Data Model and Method Framework for Cyberspace Map Visualization

ISPRS International Journal of Geo-Information
Integrating cyberspace and geographic space through map visualization is a valuable approach for revealing distribution patterns and relational dynamics in cyberspace. The interdisciplinary integration of network science and geographic science has gained
Zheng Zhang, Chenghu Zhou, Minjie Chen, Yibing Cao, Shaojing Fan   +4 more
doaj   +1 more source

Clinical characteristics and risk factors of an outbreak with scrub typhus in previously unrecognized areas, Jiangsu province, China 2013.

PLoS ONE, 2015
Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in Jingjiang City, China where the disease had not been known to exist. We analyzed epidemiological data, clinical characteristics and risk factors of scrub typhus outbreak in Jingjiang
Jianli Hu, Zhongming Tan, Dafei Ren, Xiang Zhang, Yilin He, Changjun Bao, Dapeng Liu, Qianhua Yi, Weijuan Qian, Jun Yin, Zhen Xu, Chunxia Yu, Shenjiao Wang, Bin Wu, Haiyu Yang, Ming Yue, Yun Zhang, Wendong Liu, Yefei Zhu, Minghao Zhou, Fenyang Tang   +20 more
doaj   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting-Edge Breakthroughs. [PDF]

Adv Sci (Weinh)
Advanced Science, EarlyView.
Fan K, Wei H, Yan X.
europepmc   +2 more sources

The edge fault-diameter of Cartesian graph bundles

European Journal of Combinatorics, 2009
The Cartesian product of two graphs \(G_1\) and \(G_2\), \(G_1\square G_2\), has vertex set set \(V(G_1)\times V(G_2)\). Two vertices \((u_1, v_1)\) and \((u_2, v_2)\) are adjacent in \(G_1\square G_2\) if either \(u_1u_2\in E(G_1)\) and \(v_1=v_2\) or \(v_1v_2\in E(G_2)\) and \(u_1=u_2\). A graph \(G\) is a Cartesian graph bundle with fibre graph \(F\)
Iztok Banic, Rija Erves, Janez Zerovnik
openaire   +4 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

AnImprovedMethodofGeographicTrafficInformationBased onHeatmapVisualization

工程科学与技术, 2015
:TosolvetheedgeconfusionprobleminthegraphvisualizationandshowGIS-relateddatainformation,theheatmapwasintroducedtorepresentthepathdatainformation,usingthemappingbetweenheatintensityandcolortopresentthefrequentmigration ...
聂俊岚, 辛姝悦, 张继凯, 郭栋梁   +3 more
doaj  

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source