Results 111 to 120 of about 978,529 (303)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Parameterized Algorithms and Hardness for the Maximum Edge q-Coloring Problem [PDF]

An edge q-coloring of a graph G is a coloring of its edges such that every vertex sees at most q colors on the edges incident on it. The size of an edge q-coloring is the total number of colors used in the coloring. Given a graph G and a positive integer
Panolan, Fahad, Seshikanth, Mathew, R., Mathew, Rogers, Panolan, F.   +4 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Strong Edge-Coloring Of Planar Graphs

Discussiones Mathematicae Graph Theory, 2017
A strong edge-coloring of a graph is a proper edge-coloring where each color class induces a matching. We denote by 𝜒's(G) the strong chromatic index of G which is the smallest integer k such that G can be strongly edge-colored with k colors. It is known
Song Wen-Yao, Miao Lian-Ying
doaj   +1 more source

Fast edge colorings with fixed number of colors to minimize imbalance

Journal of Graph Algorithms and Applications, 2008
We study the following optimization problem: the input is a multigraph G=(V,E) and an integer parameter g. A feasible solution consists of a (not necessarily proper) coloring of E with colors 1, 2, …, g.
Gruia Calinescu, Michael Pelsmajer
doaj   +1 more source

Parameterized Complexity of Maximum Edge Coloring in Graphs [PDF]

, 2012
The classical graph edge coloring problem deals in coloring the edges of a given graph with minimum number of colors such that no two adjacent edges in the graph, get the same color in the proposed coloring.
Goyal, Prachi
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Graph Edge Coloring: Vizing's Theorem and Goldberg's Conjecture

, 2012
Features recent advances and new applications in graph edge coloring Reviewing recent advances in the Edge Coloring Problem, Graph Edge Coloring: Vizing's Theorem and Goldberg's Conjecture provides an overview of the current state of the science ...
Scheide, Diego, Stiebitz, Michael, Favrholdt, Lene M, Toft, Bjarne   +3 more
core  

On facial unique-maximum (edge-)coloring [PDF]

, 2018
A facial unique-maximum coloring of a plane graph is a vertex coloring where on each face α the maximal color appears exactly once on the vertices of α.
Riste Škrekovski, Bernard Lidický, Borut Lužar, Vesna Andova, Luzar, Borut, Skrekovski, Riste, Lidicky, Bernard, Andova, Vesna   +7 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source