Results 91 to 100 of about 12,413 (296)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Arboricity-Dependent Algorithms for Edge Coloring [PDF]
The problem of edge coloring has been extensively studied over the years. Recently, this problem has received significant attention in the dynamic setting, where we are given a dynamic graph evolving via a sequence of edge insertions and deletions and ...
Costa, Martín +3 more
core +3 more sources
Regular Colorings in Regular Graphs
Discussiones Mathematicae Graph Theory, 2020 An (r − 1, 1)-coloring of an r-regular graph G is an edge coloring (with arbitrarily many colors) such that each vertex is incident to r − 1 edges of one color and 1 edge of a different color.
Bernshteyn Anton +6 more
doaj +1 more source
Maximal edge colorings of graphs
European Journal of CombinatoricsFor a graph $G$ of order $n$ a maximal edge coloring is a proper edge coloring with $χ'(K_n)$ colors such that adding any edge to $G$ in any color makes it improper. Meszka and Tyniec proved that for some values of the number of edges there are no graphs with a maximal edge coloring, while for some other values, they provided constructions of such ...
Sebastian Babinski, Andrzej Grzesik
openaire +6 more sources
Algorithmic Aspect of Edge-Coloring
, 2007 Vizing的定理敘述一個簡單圖 $G$ 能使用 $Delta (G)+1$ 顏色做邊著色，$Delta (G)$ 為圖 $G$ 的度數。這立即引進了分類的問題─假如最少著色數 $chi '(G)=Delta (G)$，$G$ 為 class one;否則 $G$ 為 class two。本論文延伸了Vizing的定理，介紹一個新的想法，假如我們要對 $G$的一個邊做著色且這個邊在 $k$ 顏色下滿足未飽合條件，$k leq Delta (G)$，則這個邊可使用 $k$ 個顏色中的一個顏色做著色 ...
魏廷恩, Wei, Tin-En
core
We develop the theory of the edge coloring of lattice graphs. A central role is played by a necessary and sufficient condition for a proper edge coloring of a patch of a lattice graph to induce a proper edge coloring of the entire lattice graph by ...
Kattemölle, Joris
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source