Results 81 to 90 of about 9,499 (262)

Regular Colorings in Regular Graphs

Discussiones Mathematicae Graph Theory, 2020
An (r − 1, 1)-coloring of an r-regular graph G is an edge coloring (with arbitrarily many colors) such that each vertex is incident to r − 1 edges of one color and 1 edge of a different color.
Bernshteyn Anton, Khormali Omid, Martin Ryan R., Rollin Jonathan, Rorabaugh Danny, Shan Songling, Uzzell Andrew J.   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

An upper bound for star chromatic index of simple connected sub-cubic graphs and applications

Journal of the National Science Foundation of Sri Lanka
This paper explores the star edge coloring of simple connected sub-cubic graphs, which is a more restricted way of edge coloring. The idea of star edge coloring was introduced by two mathematicians Liu and Deng in 2008, motivated by its vertex version ...
C. L. R. Fernando, A. M. C. U. M. Athapattu   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fractional Q-Edge-Coloring of Graphs

Discussiones Mathematicae Graph Theory, 2013
An additive hereditary property of graphs is a class of simple graphs which is closed under unions, subgraphs and isomorphism. Let be an additive hereditary property of graphs.
Czap Július, Mihók Peter
doaj   +1 more source

On harmonious coloring of hypergraphs [PDF]

Discrete Mathematics & Theoretical Computer Science
A harmonious coloring of a $k$-uniform hypergraph $H$ is a vertex coloring such that no two vertices in the same edge have the same color, and each $k$-element subset of colors appears on at most one edge. The harmonious number $h(H)$ is the least number
Sebastian Czerwiński
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Odd edge coloring of graphs

Ars Mathematica Contemporanea, 2015
An edge coloring of a graph G is said to be an odd edge coloring if for each vertex v ofG and each colorc, the vertexv uses the colorc an odd number of times or does not use it at all. In [5], Pyber proved that 4 colors suffice for an odd edge coloring of any simple graph.
Borut Luzar, Mirko Petrusevski, Riste Skrekovski   +2 more
openaire   +3 more sources