Results 121 to 130 of about 323,476 (264)

A nonlocal metasurface for optical edge detection in the far-field. [PDF]

Nanophotonics
Lee D, Phan HL, Kim M.
europepmc   +1 more source

Learning parallel and hierarchical mechanisms for edge detection. [PDF]

Front Neurosci, 2023
Zhou L, Lin C, Pang X, Yang H, Pan Y, Zhang Y.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

High-Endurance STO:YSZ Optoelectronic Memristors with Vertically Aligned Nanocomposite Structure for Edge Detection. [PDF]

Adv Sci (Weinh)
Wang J, Xu J, Han X, Sun W, Wang F, Zhao Z, Zhao K, Shang Y, Yang B, Wang H, Liu H, Yan X.   +11 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Advancing workpiece dimension measurement: Integrating AI-based edge detection with machine vision and coordinate measuring systems. [PDF]

PLoS One
Saif Y, Rus AZM, Yusof Y, Gu YH, Al-Masni MA, Alzaeemi SA, Al-Qershi O, Altharan YM, Al-Alimi S.   +8 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Dense extreme inception network-based edge detection with deep reinforcement learning for object localization in an underwater environment. [PDF]

Sci Rep
Praveena S, Sripada RN, Laxmi Lydia E, Gudikandhula K, Dash BB, Rout SK, Bala K.   +6 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Generalizing β-VDR-based derivative computation for robust source edge detection and depth estimation from potential field data. [PDF]

Sci Rep
Falade SC, Falade AH.
europepmc   +1 more source