Results 101 to 110 of about 6,313,537 (354)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Edge detection method for remote sensing image based on morphological variable structuring element

open access: yesJournal of Measurement Science and Instrumentation, 2018
There are problems such as incomplete edges and poor noise suppression when a single fixed morphological structuring element is used to detect the edges in remote sensing images.For this reason,a morphological edge detection method for remote sensing ...
YAO Li-juan   +3 more
doaj  

Fast Processing of Massive Hyperspectral Image Anomaly Detection Based on Cloud-Edge Collaboration

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
With the improvement of hyperspectral image resolution, existing anomaly detection algorithms find it challenging to quickly process large volumes of hyperspectral data while fully exploiting spectral information.
Yunchang Wang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sub-pixel edge detection method for miniature parts in microscopic field of view

open access: yesJournal of Measurement Science and Instrumentation, 2017
In order to improve the edge detection precision of miniature parts in microscopic field of view,a sub-pixel edge detection algorithm combining non-orthogonal quadratic B-spline wavelet transform algorithm and Zernike moment algorithm is proposed.Non ...
WU Ye-lan, QIN Yan-hong, ZHANG Zhi-jing
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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