Results 91 to 100 of about 6,313,537 (354)

Optical edge detection based on high-efficiency dielectric metasurface

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2019
Significance Edge detection is a fundamental tool in image processing, computing, and machine vision. Compared with digital processes, optical analog approaches show enormous advantages owing to its intrinsic parallel nature for high-speed operation ...
Junxiao Zhou   +8 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modeling and detection of the prepared tool edge radius

open access: yesScience Progress, 2020
Introduction: High-speed and high-efficient machining is the inevitable development direction of machining technology. The tool edge preparation can improve the life, cutting performance, and surface quality of a tool and help to achieve high-speed and ...
Zhao Xuefeng, Li Hui, He Lin, Tao Meng
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Analisis Perbandingan Perbaikan Kualitas Citra Pada Motif Batik Dengan Konsep Deteksi Tepi Robert, Sobel, Canny Menggunakan Metode Morfologi

open access: yesJurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2019
Image results from quality edge detection are not optimal. From these problems a method is needed to improve the image quality of edge detection. The method used is Dilation Morphology on the results of edge detection of batik patterns.
Muhammad Abrar Masril
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Edge Detection on Hexagonal Structure

open access: yesJournal of Algorithms & Computational Technology, 2008
Gradient-based edge detection is a straightforward method to identify the edge points in the original grey-level image. It is intuitive that in the human vision system the edge points always appear where the grey-level value is greatly changed.
Xiangjian He   +3 more
doaj   +1 more source

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