Results 71 to 80 of about 303,248 (261)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Modeling and detection of the prepared tool edge radius

Science Progress, 2020
Introduction: High-speed and high-efficient machining is the inevitable development direction of machining technology. The tool edge preparation can improve the life, cutting performance, and surface quality of a tool and help to achieve high-speed and ...
Zhao Xuefeng, Li Hui, He Lin, Tao Meng
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Edge detection method for remote sensing image based on morphological variable structuring element

Journal of Measurement Science and Instrumentation, 2018
There are problems such as incomplete edges and poor noise suppression when a single fixed morphological structuring element is used to detect the edges in remote sensing images.For this reason,a morphological edge detection method for remote sensing ...
YAO Li-juan, WANG Xiao-peng, WANG Wei, MA Wen-gang   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fast Processing of Massive Hyperspectral Image Anomaly Detection Based on Cloud-Edge Collaboration

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
With the improvement of hyperspectral image resolution, existing anomaly detection algorithms find it challenging to quickly process large volumes of hyperspectral data while fully exploiting spectral information.
Yunchang Wang, Jin Sun, Yang Xu, Zhihui Wei, Shangdong Zheng, Zebin Wu   +5 more
doaj   +1 more source

Edge Detection on Hexagonal Structure

Journal of Algorithms & Computational Technology, 2008
Gradient-based edge detection is a straightforward method to identify the edge points in the original grey-level image. It is intuitive that in the human vision system the edge points always appear where the grey-level value is greatly changed.
Xiangjian He, Qiang Wu, Wenjing Jia, Tom Hintz   +3 more
doaj   +1 more source

Analisis Perbandingan Perbaikan Kualitas Citra Pada Motif Batik Dengan Konsep Deteksi Tepi Robert, Sobel, Canny Menggunakan Metode Morfologi

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2019
Image results from quality edge detection are not optimal. From these problems a method is needed to improve the image quality of edge detection. The method used is Dilation Morphology on the results of edge detection of batik patterns.
Muhammad Abrar Masril
doaj   +1 more source