Results 161 to 170 of about 2,712,541 (299)

Edge effect pinning in mesoscopic superconducting strips with non-uniform distribution of defects. [PDF]

Sci Rep, 2019
Kimmel GJ, Glatz A, Vinokur VM, Sadovskyy IA.   +3 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

LES investigation of the wavy leading edge effect on cavitation noise. [PDF]

Ultrason Sonochem
Yang Z, Wang X, Zhao X, Cheng H, Ji B.
europepmc   +1 more source

Does the edge effect impact on the measure of spatial accessibility to healthcare providers? [PDF]

Int J Health Geogr, 2017
Gao F, Kihal W, Le Meur N, Souris M, Deguen S.   +4 more
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Pelagic cnidarian assemblages show range-edge effect at the boundary of ocean surface, as illustrated in the case of the Amazon River Plume. [PDF]

PLoS One
Tosetto EG, Neumann-Leitão S, Araujo M, Bertrand A, Júnior MN.   +4 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure propensities. [PDF]

Sci Rep
Morimoto J, Pietras Z.
europepmc   +1 more source

Edge effect of strained bilayer nanofilms for tunable multistability and actuation. [PDF]

Nanoscale, 2017
Hu N, Han X, Huang S, Grover HM, Yu X, Zhang LN, Trase I, Zhang JX, Zhang L, Dong LX, Chen Z.   +10 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source