Results 171 to 180 of about 606,440 (315)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Edge Effect and the Influence of Biotic and Abiotic Factors on Calliphoridae and Mesembrinellidae (Insecta: Diptera) in Três Picos State Park, Brazil. [PDF]

Life (Basel)
Azevedo WTA, Nunes MDP, Albuquerque VML, Lessa CSS, Alencar J, Aguiar VM.   +5 more
europepmc   +1 more source

Defining cornfield edge effect due to field microclimates [PDF]

As profit margins become increasingly smaller for Midwest farmers, it is crucial to understand how a crop reacts to weather-related stress. Cornfield edge effect is a new phenomenon Iowa farmers are experiencing where grain yield is lower at the field ...
Licht, Mark, White, Tyler R.
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Edge effect influences the ecological strategies of plant communities in tropical forest fragments. [PDF]

Plant Biol (Stuttg)
Sousa TS, Pacheco RD, Pereira L, Barbosa A, Botelho LG, Michelan TS, Cerqueira RM, Gurgel ESC, Teodoro GS.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Understanding the Nanoindentation Edge Effect of Single-Crystal Silicon Using Molecular Dynamics Simulations. [PDF]

Micromachines (Basel)
Long C, Li R, Zhao P, Li Z, Kang S, Li D, Liu H.   +6 more
europepmc   +1 more source

Hydrogel 3D printing with the capacitor edge effect. [PDF]

Sci Adv, 2019
Wang J, Lu T, Yang M, Sun D, Xia Y, Wang T.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Red edge effect of chalcone derivatives and their application in Bio-sensing. [PDF]

RSC Adv
Saha A, Karar M, Choudhury S.
europepmc   +1 more source