Results 171 to 180 of about 1,092,292 (254)

Strong k - edge odd Graceful labeling of graphs

open access: yesInternational Mathematical Forum, 2018
openaire   +1 more source

To vary or not to vary: A flexible empirical Bayes factor for testing variance components

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Random effects are the gold standard for capturing structural heterogeneity, such as individual differences or temporal dependence. Yet testing their presence is difficult because variance components are constrained to be non‐negative, creating a boundary problem. This paper introduces a flexible empirical Bayes factor (EBF) for testing random
Fabio Vieira, Hongwei Zhao, Joris Mulder
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier   +2 more
wiley   +1 more source

A Real‐Time Multi‐Scale Neural Representation for Complex Surface Reflectance

open access: yesComputer Graphics Forum, EarlyView.
Abstract Recent machine learning methods have significantly advanced the state of the art in the classic problem of representing surface appearance over angle, space, and scale. The models tend, however, to be relatively heavy compared to traditional fixed‐function representations, making real‐time application challenging.
Heikki Timonen   +2 more
wiley   +1 more source

Graceful labeling of pendant edge extension of complete bipartite graph

open access: yesInternational Journal of Mathematical Analysis, 2014
Soumya Bhoumik, Sarbari Mitra
openaire   +1 more source

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