Results 121 to 130 of about 2,473,071 (281)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Edge Modes of Scattering Chains with Aperiodic Order

, 2018
We study the scattering resonances of one-dimensional deterministic aperiodic chains of electric dipoles using the vectorial Green's matrix method, which accounts for both short- and long-range electromagnetic interactions in open scattering systems.
Luca Dal Negro (9498930), Ren Wang (188650), Christian V. Morfonios (15421799), Peter Schmelcher (15421802), Malte Rontgen (17473926), Felipe A. Pinheiro (14359908)   +5 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The search for chaotic edge localized modes in ASDEX Upgrade

Time intervals between edge localized modes (ELMs) from the ASDEX Upgrade tokamak have been analysed to determine whether the ELM dynamics is chaotic (deterministic) or random (noise dominated).
Kurki-Suonio, T., Degeling, A. W., Dumbrajs, O., Hynonen, V., Urano, H.   +4 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Suppression of Edge Localized Modes in ITER Baseline Scenario in EAST using Edge Localized Magnetic Perturbations [PDF]

We report the suppression of Type-I Edge Localized Modes (ELMs) in the EAST tokamak under ITER baseline conditions using $n = 4$ Resonant Magnetic Perturbations (RMPs), while maintaining energy confinement.
Yang, H., Yu, Y., Wan, B., Lv, B., Deng, G., Gu, S., Zhou, C., He, K., Jia, T., Sheng, H., Liang, Y., Chen, G., Team, the EAST, Zhou, Z., Zhang, T., Yan, X., Wang, S., Fu, S., Xu, W., Ye, C., Weisberg, D., Zang, Q., Qian, J., Liu, Y. Q., Loarte, A., Zeng, L., Wang, H. H., Xie, P., Jia, M., Lu, D., Wu, X., Ma, Q., Sun, Y., Paz-Soldan, C. A.   +33 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Corner Majorana states in semi-Dirac materials

JPhys Materials
Proximity-induced superconductivity in low-dimensional systems offers a powerful pathway to engineer topological superconducting phases in, otherwise, non-superconducting systems.
Marta García-Olmos, Yuriko Baba, Mario Amado, Rafael A Molina   +3 more
doaj   +1 more source