Results 91 to 100 of about 4,863,804 (250)

On the Edge Metric Dimension of Certain Polyphenyl Chains

, 2021
The most productive application of graph theory in chemistry is the representation of molecules by the graphs, where vertices and edges of graphs are the atoms and valence bonds between a pair of atoms, respectively.
Dalal Alrowaili, Sohail Zafar, Muhammad Ahsan, Imran Siddique, Aiyared Iampan, Zohaib Zahid   +5 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Cue competition affects temporal dynamics of edge-assignment in human visual cortex [PDF]

, 2011
Edge-assignment determines the perception of relative depth across an edge and the shape of the closer side. Many cues determine edge-assignment, but relatively little is known about the neural mechanisms involved in combining these cues.
Brooks, Joseph L, Palmer, Stephen E., Brooks   +2 more
core   +1 more source

Neural Network Method for Detecting Low-Intensity DDoS Attacks with Stochastic Fragmentation and Its Adaptation to Law Enforcement Activities in the Cyber Protection of Critical Infrastructure Facilities

Computers
This article develops a method for the early detection of low-intensity DDoS attacks based on a three-factor vector metric and implements an applied hybrid neural network traffic analysis system that combines preprocessing stages, competitive pretraining
Serhii Vladov, Victoria Vysotska, Łukasz Ścisło, Rafał Dymczyk, Oleksandr Posashkov, Mariia Nazarkevych, Oleksandr Yunin, Liliia Bobrishova, Yevheniia Pylypenko   +8 more
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Edge metric dimension of some Cartesian product of graphs

The edge metric dimension edim(G)of a connected graph G is the minimum cardinality of a set S of vertices such that each edge is uniquely determined by its distance from the vertices of the set S. In this work, the edge metric dimension of the prism over
T., Reji, Saritha Chandran C, Chandran C., Saritha   +2 more
core   +1 more source