Results 61 to 70 of about 4,863,804 (250)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Computation of mixed resolvability for a circular ladder and its unbounded nature.
PLoS ONELet Γ = Γ(V ,E) be a simple, planar, connected, and undirected graph. The article primarily concentrates on a category of planar graphs, detailing the explicit identification of each member within this graph family. Within the domain of graph theory, the
Sunny Kumar Sharma +5 more
doaj +1 more source
Rank-Based Methods for Selection of Landscape Metrics for Land Cover Pattern Change Detection
Remote Sensing, 2016 Often landscape metrics are not thoroughly evaluated with respect to remote sensing data characteristics, such as their behavior in relation to variation in spatial and temporal resolution, number of land cover classes or dominant land cover categories ...
Priyakant Sinha, Lalit Kumar, Nick Reid
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Hyperconvexity and endpoints in T₀-quasi-metric spaces [PDF]
, 2013 Over the last decades much progress has been made in the investigation of hyperconvexity in metric spaces. Recently Kemajou and others have published an article concerning hyperconvexity in T₀-quasi-metric spaces.
Haihambo, Paulus
core +1 more source
Adjustable edge quality metric and its applications
, 1990 This paper first proposes a new quality metric for edge evaluation, based on six physical characteristics. These physical characteristics that affect human edge quality evaluation are continuity, smoothness, thinness, localization, detection and ...
Chang, Dunkai Kyle, 1962-
core +4 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Dealing with non-metric dissimilarities in fuzzy central clustering algorithms [PDF]
, 2008 Clustering is the problem of grouping objects on the basis of a similarity measure among them. Relational clustering methods can be employed when a feature-based representation of the objects is not available, and their description is given in terms of ...
Filippone, M., Maurizio Filippone
core +1 more source
cognitivefactory/features-maximization-metric
, 2023 Release 0.1.0 of cognitivefactory/features-maximization-metric package. GitHub repository : https://github.com/cognitivefactory/features-maximization-metric/tree/0.1.0 Main documentation : https://cognitivefactory.github.io/features-maximization-metric/
Schild, Erwan
core +1 more source