Results 121 to 130 of about 2,944,639 (323)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Taha Toros Arşivi, Dosya No: 188-Vedat TürkaliUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir.
Oral, Zeynep
core
Informationstechnologie unter Erreichbarkeit –Intelligentes Transportsystem: Eine Studie für den Stadtverkehr in Istanbul [PDF]
, 2016 Die Verkehsplanung als ein Grundstein der Stadtplanung beeinflusst die Lebensqualitӓt in den Stӓdten und lenkt Mobilitӓt, sondern auch die Verbindung zwischen Stadtraum erstellt.
Ulusay-Alpay, Bilge
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Репродуктивная эндокринологияThis updated guideline offers best practice recommendations for the care of women with both primary and secondary premature ovarian insufficiency (POI). POI is a clinical condition defined by the loss of ovarian function indicated by irregular menstrual ...
Editor Editor
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
CONSTRUCTIVISM AND ITS REFLECTIONS TO TEACHING APPLICATIONS [PDF]
An effective teaching process makes it necessary primarily to know the quality of learning and how learning occurs. Learning theories explain in which conditions learning occurs.
Fatih Yilmaz +2 more
core