Results 191 to 200 of about 2,720,692 (363)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Crystallographic computing 3: Data collection, structure determination, proteins, and databases edited by G. M. Sheldrick, C. Krüger and R. Goddard [PDF]
, 1986 Jenny P. Glusker
openalex +1 more source
Editing Out Seizures? Base Editing Shows Promise for SCN8A DEE. [PDF]
Epilepsy CurrRiccio F, Lignani G.
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Spaces of Security and Insecurity: Geographies of the War on Terror – Edited by Alan Ingram and Klaus Dodds [PDF]
, 2010 Christopher Hubbard
openalex +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A Manual of New Mineral Names 1892–1978, edited by P. G. Embrey and J. P. Fuller. British Museum (Natural History) OUP New York, 1980. No. of pages: 467. Price: £24·00 [PDF]
, 1982 Derek Flinn
openalex +1 more source