Results 131 to 140 of about 1,249,658 (312)

Design Ltd.: Renovated Myths for the Development of Socially Embedded Technologies [PDF]

, 2013
This paper argues that traditional and mainstream mythologies, which have been continually told within the Information Technology domain among designers and advocators of conceptual modelling since the 1960s in different fields of computing sciences ...
Cabitza, Federico, Simone, Carla
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Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Timber roof structure for outdoor auditorium in Parque Paraiso, San Blas (Madrid)

, 2009
p. 468-475A timber shell structure is designed to provide covering for an outdoor auditorium in Madrid (Spain). The covering comprises five independent overlapped marquees with similar shape but diverse dimensions.
ANTON, Arturo, CORBAL, Jesus J., MEIJIDE, Antonio G.   +2 more
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Exporting a Brand: A Comparative Analysis of the French Model Brand Elle Decoration with the American Edition Elle Decor [PDF]

, 2016
This thesis explores the history and editorial design of the French and American publications within the ELLE Déco brand network. The ELLE Déco network of interior design magazines is the only truly global brand of the shelter category with 25 editions ...
Hayes, Kate
core   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Editorial: Design, Synthesis, and Preclinical Testing of Innovative Anti-Cancer Compounds With a High Level of Selectivity of Action and Low Toxicity. [PDF]

Front Mol Biosci, 2022
Ferreira AMDC, Schneider-Stock R, Aiello F.   +2 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Editorial Practices of African Journals: A Qualitative Analysis from Kenya, Ethiopia, Nigeria, and Mozambique [version 1; peer review: awaiting peer review]

Gates Open Research
Introduction Information on journal visibility helps researchers decide where to publish. Some quality indicators used are directly associated with the journal’s editorial practices.
Alphonsus Neba, Emmy Igonya, Julius Kirimi Sindi, Marta Vicente-Crespo, Daniel Krugman, Patrick Amboka, H Kariuki, Abel Simiyu, Nosa Orobaton, Benard Ondiek   +9 more
doaj   +1 more source

Design e Redesign de produtos editoriais na empresa Tuttirev Editorial [PDF]

, 2016
O presente Relatório de Estágio deve ser entendido como uma observação teórica sobre o Design Editorial, o Design de revistas de cultura e lazer e o redesign da revista Casas de Madeira, realizadas no âmbito de Estágio Curricular na empresa Tuttirev ...
Pereira, Mariana Figueira
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