Results 141 to 150 of about 333,099 (310)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

Nova experiência literária através do design editorial [PDF]

open access: yes, 2019
Trabalho de Conclusão de Curso (Graduação)Entender que um livro vai além de inúmeras páginas corridas e uma capa que chama a atenção, onde o atrativo acaba ali, na primeira página virada, é essencial para um projeto editorial que busca valorizar a ...
Cheung, Bianca Dias
core  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

open access: yesAdvanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng   +9 more
wiley   +1 more source

Light & Splendour / Richard Crabbe's Celebration of Painting / Identity & Editorial Design

open access: yes, 1997
Identity & Editorial Design for the LIGHT & SPLENDOUR / Richard Crabbe's Celebration of Painting exhibition at Aspen Gallery ...
Hutchinson, Tim
core  

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

open access: yesAdvanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta   +10 more
wiley   +1 more source

Adapting to Changing Rainfall and Developing Off‐Farm Employment: Implications for the Adoption of Direct Seeding in Rice Production

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Rice is the main staple food for more than half of the world's population and the income from rice is an essential source for livelihoods of millions of households. We examine whether direct seed in rice production is an adaptation of rice farmers to rainfall changes and farm labor scarcity.
Manh Hung Do
wiley   +1 more source

Gallery Provocations: 04 A Year On / Editorial Design

open access: yes, 2010
Editorial design for the 'Gallery Provocations: 04 A Year On' exhibition & event at London College of ...
Hutchinson, Tim
core  

Birds Eye View of Editorial Design 2012 - 2020 [PDF]

open access: yes, 2016
This conference presentation looked at the state of editorial design and presented the following questions: Where Have we been? Where are we now?
Caldwell, Cath
core  

Drivers of Precision Agriculture Adoption in Italian Viticulture

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines the main drivers influencing the adoption of two types of precision farming technologies in the viticultural sector: Decision Support Systems (DSSs) and Variable Rate Technologies (VRTs). We apply a partial proportional odds model and find that socio‐demographic characteristics are not significant determinants of adoption ...
Olimpia Fontana   +3 more
wiley   +1 more source

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