Results 131 to 140 of about 1,261,430 (311)

Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia

Advanced Science, EarlyView.
A continuous, multi‐domain characterization of cognitive decline across the Alzheimer's disease spectrum identifies when individual cognitive measures become abnormal. Episodic memory declines first, followed by executive function, language, processing speed, and visuospatial abilities, supporting improved clinical interpretation and optimized endpoint
Fredrik Öhman, Lars Lau Raket, Michael Schöll, for the Alzheimer's Disease Neuroimaging Initiative†   +3 more
wiley   +1 more source

Internet y la mosca del vinagre [PDF]

, 2013
The daily expansion of the Internet, both in volume and an importance, calls for an analisys of the situation in order to find valid rules or parameters.
Larrea, Quim
core  

Design editorial

, 2019
N ...
openaire   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Editorial: Design, Synthesis, and Preclinical Testing of Innovative Anti-Cancer Compounds With a High Level of Selectivity of Action and Low Toxicity. [PDF]

Front Mol Biosci, 2022
Ferreira AMDC, Schneider-Stock R, Aiello F.   +2 more
europepmc   +1 more source

Digital Tectonics as a Morphogenetic Process

, 2010
p. 938-948Tectonics is a seminal concept that defines the nature of the relationship between architecture and its structural properties. The changing definition of the symbiotic relationship between structural engineering and architectural design may ...
OXMAN, Rivka
core  

ANALISIS KOHESI GRAMATIKAL DAN LEKSIKAL PADA TAJUK RENCANA HARIAN THE JAKARTA POST [PDF]

, 2011
Zaharil.Anasy.A4C106001. 2011. Analisis Kohesi Gramatikal dan Kohesi Leksika pada Tajuk Rencana Harian The Jakarta Post. Tesis. Program Pasca Sarjana Universitas Diponegero Semarang. Penelitian ini adalah penelitian pada bidang wacana.
Anasy, Zaharil
core  

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Editorial Practices of African Journals: A Qualitative Analysis from Kenya, Ethiopia, Nigeria, and Mozambique [version 1; peer review: awaiting peer review]

Gates Open Research
Introduction Information on journal visibility helps researchers decide where to publish. Some quality indicators used are directly associated with the journal’s editorial practices.
Alphonsus Neba, Emmy Igonya, Julius Kirimi Sindi, Marta Vicente-Crespo, Daniel Krugman, Patrick Amboka, H Kariuki, Abel Simiyu, Nosa Orobaton, Benard Ondiek   +9 more
doaj   +1 more source