Results 141 to 150 of about 1,246,423 (311)
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, EarlyView.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Timber roof structure for outdoor auditorium in Parque Paraiso, San Blas (Madrid)
, 2009 p. 468-475A timber shell structure is designed to provide covering for an outdoor auditorium in Madrid (Spain). The covering comprises five independent overlapped marquees with similar shape but diverse dimensions.
ANTON, Arturo +2 more
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Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Smart energy systems and 4th generation district heating
International Journal of Sustainable Energy Planning and Management, 2016 Energy systems are becoming increasing increasingly complex, integrating across traditionally separate sectors such as transportation, heating, cooling and electricity.
Poul Alberg Østergaard +2 more
doaj +1 more source
Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases
Advanced Science, EarlyView.Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh +17 more
wiley +1 more source
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, EarlyView.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Design Ltd.: Renovated Myths for the Development of Socially Embedded Technologies [PDF]
, 2013 This paper argues that traditional and mainstream mythologies, which have been continually told within the Information Technology domain among designers and advocators of conceptual modelling since the 1960s in different fields of computing sciences ...
Cabitza, Federico, Simone, Carla
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Advanced Science, EarlyView.Soybean production is severely threatened by salt stress. This study reveals that the GmSIN1‐GmRNF1a‐GmCSN5a module enhances salt tolerance by stabilizing the GmSIN1 protein. GmRNF1a acts as an E3 ligase to ubiquitinate GmSIN1 for degradation, a process inhibited by GmCSN5a.
Jinlong Xu +15 more
wiley +1 more source
Brandbook Russian and foreign universities: a comparative analysis [PDF]
, 2017 This article shows the analysis of domestic and foreign university brand books by 3 aspects: the structure, the content and the design. The received results reflect the general and various features of manifestation of this editorial product.В статье ...
Бочарова, А. И.
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Shedding Light on Common Misinterpretations in Photocatalyst Characterization
Advanced Energy Materials, EarlyView.For heterogeneous semiconductor‐based photocatalysts, Marschall et al. highlight common misconceptions in material synthesis, characterization, and performance evaluation, together with detailed explanations on how to avoid them. The guidelines thus presented can help to improve reporting of photocatalyst performance in environmental applications, such
Roland Marschall +2 more
wiley +1 more source