Results 41 to 50 of about 1,249,658 (312)
Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies [PDF]
, 2014 There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease.
A Billiau +34 more
core +4 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Design Science: Why, What and How – Revisited
Design ScienceDesign Science is the discipline that studies the creation of artifacts – products, services, and systems and their embedding in our physical, virtual, psychological, economic, and social environments.
Panos Papalambros +40 more
doaj +1 more source
Approaching English literature to primary and secondary education readers from Edgar Allan Poe’s short stories [PDF]
, 2018 El presente trabajo pretende acercar la literatura universal inglesa a los lectores de Educación Primaria y Secundaria desde el disfrute de la lectura de Edgar Allan Poe.
López Pérez, Magdalena +1 more
core +4 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Вопросы современной педиатрии, 2017 The guidelines for preparation of manuscripts describing clinical cases in children are presented. The guidelines are considered in a new editorial design standard which is presented in the template of the same name.
Ruslan T. Saygitov +1 more
doaj +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Bridging the theory and practise gap in emergency services research: the case for a new journal [PDF]
, 2012 Purpose - The paper aims to provide the rationale underpinning this new journal in addressing the apparent gap and fragmented nature of the emergency services research, to introduce the papers in this inaugural issue and encourage readers and potential ...
Murphy, P, Wankhade, P
core +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
FORMakademisk, 2017 This special issue of Form Akademisk consist of four selected peer reviewed articles developed from papers held at The 3rd International Conference for Design Education Researchers - DRS/CUMULUS learnxdesign conference held in Chicago from the 28th of ...
Nina Scott Frisch, Silje Bergman
doaj +1 more source