Results 291 to 300 of about 618,648 (346)

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Editorial: Social aspects of crop genome editing. [PDF]

Front Genome Ed
Venkataraman S, Hefferon K.
europepmc   +1 more source

A Phase 1, Randomized, Open‐Label, Parallel Group Study to Evaluate the Relative Bioavailability and Safety of Subcutaneous Bepirovirsen when Delivered from a Vial or Prefilled Syringe Fitted with a Safety Syringe Device in Healthy Adult Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bepirovirsen, an antisense oligonucleotide in development for the treatment of chronic hepatitis B virus (HBV) infection, is administered from glass vials as a subcutaneous (SC) injection by healthcare professionals (HCPs). A ready‐to‐use prefilled syringe (PFS) assembled with a safety syringe device (SSD) has been developed to make ...
Amir S. Youssef, Poonam Shah, Maxwell Hu, Helene Plein, Abhishek Roy, Ravi Sharma, Sarah Mole, Magdalena Blazejczyk, Wendy Cross, Brian Spears, Samuel Pak, Rejbinder Kaur, Robert Elston, Dickens Theodore, Marjan Hezareh, Ahmed Nader   +15 more
wiley   +1 more source

Retraction: HIF-1α affects the neural stem cell differentiation of human induced pluripotent stem cells via MFN2-Mediated Wnt/β-Catenin signaling. [PDF]

Front Cell Dev Biol
Frontiers Editorial Office.
europepmc   +1 more source

Family's socioeconomic and demographic factors on elements of children's dental and oral health: A scoping review

Clinical and Experimental Dental Research, EarlyView.
Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila, Mugia B. Rahardja, Puguh Prasetyoputra, Anne A. Suwargiani, Yanu E. Prasetyo, Eriska Riyanti   +5 more
wiley   +1 more source

Investigating Factors for an Inclusive Workforce for Women in the Logistics and Supply Chain Industry

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study seeks to identify and analyze the major factors that contribute to an inclusive workforce for women in the area of logistics and supply chain. It further addresses the need for gender diversity and inclusivity in a traditionally male‐dominated field by adopting a human‐centric approach.
Vernika Agarwal, Shefali Srivastava, Ashish Dwivedi, Sanjoy Kumar Paul, Anchal Patil   +4 more
wiley   +1 more source

Publishing gold standard science. [PDF]

J Clin Invest
McNally EM, Jackson S, Williams CL, Eickelberg O.   +3 more
europepmc   +1 more source

Retraction: Asthmatic airway vagal hypertonia involves chloride dyshomeostasis of preganglionic neurons in rats. [PDF]

Front Neurosci
Frontiers Editorial Office.
europepmc   +1 more source

Retraction: RAB31 targeted by MiR-30c-2-3p regulates the GLI1 signaling pathway, affecting gastric cancer cell proliferation and apoptosis. [PDF]

Front Oncol
Frontiers Editorial Office.
europepmc   +1 more source

Synaptopodin-2 Plays an Important Role in the Metastasis of Breast Cancer via PI3K/Akt/mTOR Pathway [Retraction]. [PDF]

Cancer Manag Res
europepmc   +1 more source