Results 51 to 60 of about 1,435,025 (236)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Editor’s Note. Towards an Intelligent Society: Advances in Marketing and Neuroscience
International Journal of Interactive Multimedia and Artificial Intelligence, 2019 This Special Issue focuses in cases that explore the relationship between Artificial Intelligence and marketing, as well as neuroscience. AI can be combined with specific neuroscience techniques to achieve a more successful and profitable neuromarketing.
Francisco Mochón +1 more
doaj +1 more source
Editorial: Sweet sixteen [PDF]
, 2018 This is the traditional triennial note used by the editors to give the readers of 4OR information on the state of the journal and its future. In the 3years that have passed since the last editorial note (Liberti et al.
Crama, Yves +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
IJIMAI Editor's Note - Vol. 5 Issue 3 - 10th Anniversary
International Journal of Interactive Multimedia and Artificial Intelligence, 2018 The International Journal of Interactive Multimedia and Artificial Intelligence - IJIMAI (ISSN 1989 - 1660) provides an interdisciplinary forum in which scientists and professionals can share their research results and report new advances on AI tools or ...
Rubén González Crespo
doaj +1 more source
Ethical Bedrock Under a Changing Negotiation Landscape [PDF]
, 2017 Editors\u27 Note: Your dilemmas as a negotiator fall into two basic sets, “what’s possible?” and “what\u27s right?” The first is treated by many chapters in this book.
Gibson, Kevin
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source