Results 51 to 60 of about 2,185,693 (188)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Editors\u27 Note

open access: yes, 2021
Editors\u27 Note for the Proceedings of the 2020 Annual Meeting on Phonology (AMP 2020), held at the University of California, Santa Cruz in September ...
Bennett, Ryan   +7 more
core   +1 more source

IJIMAI Editor's Note - Vol. 4 Issue 4

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2017
The research works presented in this issue are based on various topics of interest, among which are included: Radar Clutter, Radar Detectors Performance, Butterfly Optimization Algorithm, Artificial Bee Colony, Evolutionary strategy, Fractal Coding, User
Rubén González Crespo
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

IJIMAI Editor's Note - Vol. 4 Issue 2

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2016
The research works presented in this regular issue cover different fields of application such as medicine, industry or education, proposing solutions based on various topics of interest, as for example: neural networks, neuro-fuzzy systems, case-based ...
Elena Verdú
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

IJIMAI Editor's Note - Vol. 5 Issue 2

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2018
The International Journal of Interactive Multimedia and Artificial Intelligence (IJIMAI) provides an interdisciplinary forum in which scientists and professionals share their research results and report new advances on tools that use AI with interactive ...
Daniel Burgos   +2 more
doaj   +1 more source

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