Results 61 to 70 of about 2,185,693 (188)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
IJIMAI Editor's Note - Vol. 4 Issue 1
International Journal of Interactive Multimedia and Artificial Intelligence, 2016 The research works presented in this issue are based on various topics of interest, among which are included: Pattern Recognition, Multimedia Information Retrieval, Knowledge extraction and knowledge mining, Data mining, Intelligent Systems & Artificial ...
Mohamed Bahaj
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
IJIMAI Editor's Note - Vol. 4 Issue 5
International Journal of Interactive Multimedia and Artificial Intelligence, 2017 Although Medicine has always been considered a Health Science, today it is not possible to obviate its relationship with other disciplines as Humanities and Basic Sciences.
Jose Luis Cebrián Carretero
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2014 In their note, the editors thank the contributors and give an overview of the latest news regarding the ...
Yrsa Neuman +2 more
core +2 more sources
IJIMAI Editor’s Note - Vol. 2 Issue 1
International Journal of Interactive Multimedia and Artificial Intelligence, 2013 This special issue “Artificial Intelligence and Social Application” includes extended versions of selected papers from Artificial Intelligence and Education area of the 13th edition of the Ibero-American Conference on Artificial Intelligence, held in ...
Elisa Boff, Juan Pavón Mestras
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source