Results 61 to 70 of about 1,424,891 (239)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

IJIMAI Editor's Note - Vol. 4 Issue 2

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2016
The research works presented in this regular issue cover different fields of application such as medicine, industry or education, proposing solutions based on various topics of interest, as for example: neural networks, neuro-fuzzy systems, case-based ...
Elena Verdú
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

IJIMAI Editor's Note - Vol. 5 Issue 2

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2018
The International Journal of Interactive Multimedia and Artificial Intelligence (IJIMAI) provides an interdisciplinary forum in which scientists and professionals share their research results and report new advances on tools that use AI with interactive ...
Daniel Burgos   +2 more
doaj   +1 more source

A note from the editors: the state of the political constitution [PDF]

open access: yes, 2013
The revival of the political constitution has come about in parallel with two developments, one in constitutional practice and the other in political theory.
Goldoni, M., McCorkindale, C.
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

IJIMAI Editor's Note - Vol. 4 Issue 1

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2016
The research works presented in this issue are based on various topics of interest, among which are included: Pattern Recognition, Multimedia Information Retrieval, Knowledge extraction and knowledge mining, Data mining, Intelligent Systems & Artificial ...
Mohamed Bahaj
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

IJIMAI Editor's Note - Vol. 4 Issue 5

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2017
Although Medicine has always been considered a Health Science, today it is not possible to obviate its relationship with other disciplines as Humanities and Basic Sciences.
Jose Luis Cebrián Carretero
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy