Results 111 to 120 of about 5,237,043 (253)

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

open access: yesAdvanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang   +12 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye   +6 more
wiley   +1 more source

Workshop "Reading Edo-period texts in the raw" à la British Library : appel à participation

open access: yes, 2011
Le workshop "Reading Edo-period texts in the raw: learning how to read manuscripts and woodblock-printed books as Edo-period readers read them" aura lieu à la British Library (London, UK) du mercredi 27 juin 2012 au vendredi 29 juin 2012. Ce workshop est
crjehess
core  

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

open access: yesAdvanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree   +18 more
wiley   +1 more source

Archaeology through Art : Japanese Vernacular Craft in Late Edo-Period Woodblock Prints

open access: yes, 2010
This thesis examines depictions of wooden boats in Japanese woodblock prints of the late Edo period (1603 - 1867). Watercraft were an integral part of Edo Japan, yet little Western scholarship has examined their role.
Damian, Michelle M.   +1 more
core   +2 more sources

Water in Edo-Tokyo’s urban space

open access: yes, 2021
Issue 169/2021 di "Storia urbana" su "Water in Edo-Tokyo’s urban space" con contributi di: Rosa CAROLI, Inventing Edo, Rethinking Edo-­Tokyo: Water and the City; Yuko TANAKA, Waterside Culture in Edo; Fumiko KOBAYASHI, Representations of Edo-­Tōkyo ...
Caroli Rosa, Caroli, Rosa
core  

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li   +9 more
wiley   +1 more source

Mapping Ezochi : The Cartography and Representation of Japan’s Northern Frontier in Japanese maps in the Edo period. [PDF]

open access: yes, 2012
This paper examines the cartography of Japan’s northern frontier in Japanese maps in the Edo period. Between the seventeenth and nineteenth centuries, Hokkaido (the northernmost island of Japan) was divided politically into two areas _Wajinchi, the area ...
米家 志乃布
core  

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

open access: yesAdvanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi   +10 more
wiley   +1 more source

The Household and Its Discontents: Ejima Kiseki's Seken Musuko Katagi

open access: yesJapanese Language and Literature
This article examines the “character pieces” (katagi-mono) of Ejima Kiseki (1666–1735), with a focus on Seken musuko katagi (Characters of Worldly Young Men, 1715), in the context of the normalization of the townsman household (ie) around the turn of ...
Thomas Gaubatz
doaj   +1 more source

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