Results 121 to 130 of about 5,237,043 (253)

'My condition gets worse day by day' : controlling traveling bodies on the move in Edo-period Japan

open access: yes, 2023
Traveling can challenge physical awareness and makes the traveler aware of his/her body, which in daily life tends to disappear under layers of bodily routines.
Maruo-Schröder, Nicoleeditor   +3 more
core  

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

open access: yesAdvanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li   +7 more
wiley   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

open access: yesAdvanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen   +8 more
wiley   +1 more source

A Scalable Spin‐Coating Strategy for Mesoporous Gold Thin Films toward miRNA Detection

open access: yesAdvanced Science, EarlyView.
A scalable spin‐coating strategy produces uniform mesoporous Au thin films with tunable thickness and high electroactive surface area on transparent substrates. The resulting architecture enables label‐free, amplification‐free detection of ovarian cancer‐associated miRNA hsa‐miR‐200c‐3p from 1 aM to 10 pM, achieving a 1.72 aM detection limit with high ...
Aditya Ashok   +8 more
wiley   +1 more source

Underground Japan: Metamorphosis of the Organized Crimes from the Edo Period until Present Times

open access: yes, 2019
Bakalaura darbs “Pazemes Japāna: organizētās noziedzības metamorfoze no Edo perioda līdz mūsdienām“ ir veltīts organizēto noziedzīgo grupu attīstībai Japānā, pazīstamas kā jakudza.
Tarnavskaya, Anna
core  

Deposition Rate‐Controlled Functional Evolution of p‐Type Selenium‐Alloyed Tellurium–Tellurium Oxide Films for Thin‐Film Transistors

open access: yesAdvanced Science, EarlyView.
This study investigates the effects of thermal deposition rate on next‐generation p‐type amorphous oxide semiconductor SeTe–TeOx films. Deposition rate governs the chemical states, microstructure, and electrical characteristics of the films, resulting in tunable device properties.
Seongmo Kang   +8 more
wiley   +1 more source

Japanese Falconry in the Edo Period

open access: yes
During the Edo period(l603-1867), falconry (known as takagari in Japan) was actively practiced among the shoguns and daimyos. The first part of this article describes the falconry practices used by the successive shoguns of the Edo shogunate and the ...
TAKEI, Koichi   +2 more
core  

Gift Exchanges in Edo Castle [PDF]

open access: yes, 2012
The Japanese love of gift-giving was firmly established during the Edo period, specifically under the fifth shogun Tsunayoshi. This study was done as part of inquiry into the institution of Ooku, and I remark on the significance of gift exchanges as ...
Seigle, Cecilia S, Ph.D.
core  

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

open access: yesAdvanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie   +7 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

open access: yesAdvanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang   +8 more
wiley   +1 more source

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