Results 91 to 100 of about 16,645 (269)

Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study

Fundamental &Clinical Pharmacology, Volume 39, Issue 6, December 2025.
ABSTRACT Background Direct‐acting oral anticoagulants (DOACs) have largely replaced warfarin for stroke prevention in patients with atrial fibrillation, yet their population‐level impact on health outcomes and costs remains unclear. We examined whether the widespread uptake of DOACs was associated with changes in hospitalization rates and costs for ...
Tony Antoniou, Daniel McCormack, Tianru Wang, Mina Tadrous, Tara Gomes   +4 more
wiley   +1 more source

Association of Anaesthetists guidelines: safe vascular access 2025

Anaesthesia, Volume 80, Issue 11, Page 1381-1396, November 2025.
Summary Introduction Safe vascular access is integral to anaesthetic and critical care practice. However, despite technological and procedural advances, it remains a frequent source of adverse events and patient harm. Ensuring a safe and effective approach to the selection, insertion and care of vascular access devices should be a priority for all ...
Andrew J. Johnston, Matthew J. Simpson, Victoria McCormack, Andrew Barton, James Bennett, Anil Chalisey, Jeremy Crane, Stefanie Curry, Helen Laycock, Dhupal Patel, Teikchoon See, John Shubhaker, Kathryn Singh, Sarah Thornton   +13 more
wiley   +1 more source

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. [PDF]

, 2018
It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein
Burra, P, Campello, E, Russo, Fp., Simioni, P, Spiezia, L, Zanetto, A   +5 more
core   +1 more source

Adjustment for ‘Prescriber Type’ in Pharmacoepidemiological Analyses

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT The type of prescriber typically fulfils the criteria for confounding, as it is associated both with the exposure (e.g., prescriber types may differ in their choice of first‐line treatment) and with the outcome (as different types of prescribers often treat patients with different disease severity).
Saad Hanif Abbasi, Jesper Hallas, Peter Bjødstrup Jensen, Hassan Al‐Jasim, Anton Pottegård   +4 more
wiley   +1 more source

Clinical associations and prognosis in Asian and European patients with symptom‐controlled atrial fibrillation: Insights from two prospective registries in Europe and Asia

European Journal of Clinical Investigation, Volume 55, Issue 11, November 2025.
Symptom‐controlled atrial fibrillation (AF), defined as asymptomatic or with mild symptoms according to the European Heart Rhythm Association (EHRA) score, was more common among Asians than in Europeans. In Asians, comorbidities of diabetes, hypertension, and prior ischemic stroke increase the likelihood of being scAF.
Wee Siong Teo, Manlin Zhao, Tommaso Bucci, Steven Ho Man Lam, Hongyu Liu, Yang Chen, Giuseppe Boriani, Hung‐Fat Tse, Tze‐Fan Chao, Gregory Y. H. Lip   +9 more
wiley   +1 more source

Oral anticoagulation in patients with gastrointestinal bleeding and new‐onset atrial fibrillation: A population‐based registry‐linkage study

Journal of Internal Medicine, Volume 298, Issue 5, Page 450-463, November 2025.
Abstract Background Limited data exist on the prevalence of gastrointestinal bleeding (GIB) in patients with new‐onset atrial fibrillation (AF) and the impact of GIB on the initiation of oral anticoagulation (OAC) therapy. Methods A population‐based registry‐linkage study included all patients diagnosed with new‐onset AF in Finland during 2010–2018 who
Santeri Jolkkonen, Jukka Putaala, Konsta Teppo, Pirjo Mustonen, Jussi Jaakkola, Aapo Aro, Olli Halminen, Ossi Lehtonen, Jari Haukka, Miika Linna, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto   +12 more
wiley   +1 more source

Determination of Edoxaban in Bulk and in Tablet Dosage Form by Stability Indicating High-Performance Liquid Chromatography

Pharmaceutical Sciences, 2016
Background: Edoxaban is an orally active direct factor Xa inhibitor. The aim of the present study was to develop a stability indicating HPLC method for the quantification of edoxaban in bulk and in tablet dosage form. Methods: Edoxaban was separated on
Pasam Satyanarayana Reddy , V. Shanmukha Kumar Jagarlapudi, Chandra Bala Sekaran
doaj   +1 more source

Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation? [PDF]

, 2018
© 2018 Bentham Science PublishersBACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term.
Akhtar, Zaki, Farag, Mohamed, Gorog, Diana Adrienne, Spinthakis, Nikolaos   +3 more
core   +2 more sources

Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF‐β

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Platelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Rui Chen, Emily Huang, Xianfang Wu, Megan R. McMullen, Xianjia Wang, Laura E. Nagy, Ge Jin, Scott J. Cameron, Thomas M. McIntyre   +8 more
wiley   +1 more source

Ex vivo reversal of the anticoagulant effects of edoxaban

Thrombosis Research, 2014
Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa) and factor VIII inhibitor bypass activity ...
Abdel-Baset Halim, Meyer Michel Samama, Jeanne Mendell   +2 more
openaire   +3 more sources