Results 191 to 200 of about 915,693 (265)

Effect of different irrigation regimen on sealability and push-out bond strength of biodentine when used for repair of furcal perforation in mandibular permanent molars: An <i>in vitro</i> study. [PDF]

J Conserv Dent Endod
Moorthy K, Surendran S, Ulaganathan S, Natanasabapathy V.   +3 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Alcalase-Flavourzyme Red Seaweed Hydrolysates as Antioxidants to Enhance Oxidative Stability of DHA Nanoemulsions. [PDF]

Foods
Ghelichi S, Shokrollahi Yancheshmeh B, Helalat SH, Jacobsen C.   +3 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Staufen purification: challenges and opportunities. Protocols and troubleshooting. [PDF]

MethodsX
Shakoor H, Tripepi A.
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Over four minutes of pyruvate T₁ using chemically and physically induced deceleration of relaxation. [PDF]

Nat Commun
Peters JP, Teleanu F, Zou H, Rasool E, Haj Mohamad F, Schäfer H, Hövener JB, Jerschow A, Pravdivtsev AN.   +8 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Evaluation of debris and smear layer removal efficacy of different irrigating solutions using the C-RCC irrigation system: An <i>in vitro</i> SEM study. [PDF]

J Conserv Dent Endod
Goyal M, Agarwal A, Roy A, Jain D, Shandilya A, Kunhappan S.   +5 more
europepmc   +1 more source

Structural and functional characterization of human kallistatin. [PDF]

Biochem Biophys Rep
Pham STD, Nielsen KW, Graversen JH, Kristensen N, Steffensen LB, Lundgaard AR, Martín-Ventura JL, Højrup P, Palarasah Y.   +8 more
europepmc   +1 more source