Results 61 to 70 of about 1,446,102 (311)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The effect of Morinda Citrifolia juice as an endodontic irrigant on smear layer and microhardness of root canal dentin [PDF]

, 1925
PurposeThe purpose of this study was to evaluate the effect of Morinda Citrifolia Juice (MCJ) on smear layer removal and microhardness value of root canal dentin in compared with various endodontic irrigants.Material and methodsEighty-four single-rooted ...
Saghiri, Mohammad Ali, García-Godoy, Franklin, Asgar, Kamal, Lotfi, Mehrdad   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Lead Phyto extraction in the Huachipa Zoological Park through the use of Tagetes erecta associated with a mycorrhiza and EDTA

Peruvian Journal of Agronomy, 2020
Phytoremediation is a potentially less costly approach to treat contaminated soil. Here, the phytoremediation capacity of marigold (Tagetes erecta) in conjunction with EDTA and mycorrhizae was analyzed.
O. Carrera, L. Tello
doaj   +1 more source

Rotavirus 993/83, isolated from calf faeces, closely resembles an avian rotavirus [PDF]

, 1992
Polypeptides from purified virions of the calf rotavirus (RV) isolate 993/83 and those from the pigeon RV isolate PO-13 comigrated on SDS-polyacrylamide gels. Two polypeptides of 45K and 47K were detected at the position of VP6.
Büssow, Harald, Eichhorn, Werner, Minamoto, Nobuyuki, Nakagomi, Osamu   +3 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of ethylenediamine tetraacetic acid (EDTA) and maleic acid as root-end conditioners on the sealing ability of ProRoot mineral trioxide aggregate (MTA) and Biodentine as root-end filling materials: An in vitro study [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Apicoectomy is often required to treat a non-healing endodontic lesion. Materials used during this procedure, such as root-end conditioners and retrograde filling materials, can significantly affect the success.
Sumaiya Zafar, Yawar Ali Abidi, Samira Adnan, Maham Muneeb Lone, Farah Afroz Khan, Isma Sajjad   +5 more
doaj   +1 more source

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Imamovic, Lejla, Muniesa Pérez, Ma Teresa   +1 more
core   +2 more sources