Results 51 to 60 of about 659,434 (234)

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source

A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial

Aging Cell, Volume 25, Issue 2, February 2026.
In frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Gloria Olaso‐Gonzalez, Fernando Millan‐Domingo, Luis Garcia‐Fernandez, Elisa Garcia‐Tercero, Monica Cebrian, Cristina Garcia‐Dominguez, Juan Antonio Carbonell, German Casabo‐Valles, Jose Luis Garcia‐Gimenez, Eva Tamayo‐Torres, Juan Gambini, Francisco Jose Tarazona‐Santabalbina, Jose Vina, Maria Carmen Gomez‐Cabrera   +13 more
wiley   +1 more source

Recomendaciones para la terapia oral anticoagulante [PDF]

, 2015
Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de MadridIntroducción: en España existen aproximadamente 1 millón de pacientes con tratamiento ...
Carmena Hernández, Ana Isabel, Cobos Carvajal, María José, Vidal Salcedo, Ana   +2 more
core   +4 more sources

Impacto de la educación sanitaria escolar, hacinamiento y parasitosis intestinal en niños preescolares

Comuni@cción, 2019
La presente investigación estudió el impacto de la enteroparasitosis en niños y analiza el papel de la educación sanitaria en la promoción de la salud en niños y familiares del Centro Educativo Inicial Estatal “Paz y Amor” de la Región Callao (Perú ...
Noemí Zuta Arriola, Arcelia Olga Rojas Salazar, Manuel Alberto Mori Paredes, V. Bravo   +3 more
semanticscholar   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, Volume 38, Issue 2, 8 January 2026.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source

Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines

ChemMedChem, Volume 21, Issue 2, January 2026.
Natural products and/or their structural analogs represent the greatest number of approved small‐molecules as antitumor agents. We report the synthesis of 2‐propanamide and 2‐propanamine dihydrobenzopyrans and 2‐ and 2,3‐disubstituted quinolines to evaluate their cytotoxicity against human A549 (lung), A2058 (melanoma), HepG2 (liver), MCF‐7 (breast ...
Bernabeu‐Sanchis Álvaro, Thomas A. Mackenzie, Maria C. Ramos, Ainhoa García, Carlos Villarroel‐Vicente, Laura Vila, José R. Tormo, Diego Cortes, Nuria Cabedo   +8 more
wiley   +1 more source

La importancia de la educación sanitaria en la lactancia materna [PDF]

, 2015
Trabajo fin de grado de EnfermeríaLa importancia de la lactancia materna (LM) es evidente tanto para recién nacidos como para las madres. Se ha realizado una revisión narrativa en las principales bases de datos sanitarias.
Sacristán Leal, Jorge
core  

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

Advanced Functional Materials, Volume 35, Issue 52, December 23, 2025.
Platinum‐Copper bimetallic nanoparticles may evolve depending on their synthesis under tumor microenvironment conditions and play a dual role as chemotherapeutic agents after releasing Cu ions and as near infrared photothermal agents with the Pt‐rich remaining frames.
Jose I. Garcia‐Peiro, María Sancho‐Albero, Silvia Miguel, Andrea Mosseri, Felipe Hornos, Rafael Contreras‐Montoya, Jose L. Hueso, Jesus Santamaria   +7 more
wiley   +1 more source

Modificación de los estilos de vida y factores de riesgo en la hipertensión arterial [PDF]

, 2015
Treball Final de Grau en Infermeria. Codi: IN1138. Curs: 2014/2015Introducción: Las enfermedades cardiovasculares plantean una serie de problemas en diferentes ámbitos y no sólo a nivel asistencial. La hipertensión arterial, es en la población adulta, el
López Negre, Marta
core