Pubertal development and hypothalamic-pituitary-gonadal axis are altered in male mice lacking Mecp2. [PDF]
J NeuroendocrinolAbstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Martín-Sánchez A +6 more
europepmc +2 more sources
A novel integrated miRNA-donor age signature enables detection of cardiac allograft vasculopathy. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 16, Issue 3, March 2026.
González-Torrent I +6 more
europepmc +2 more sources
Advancing our understanding of valued living: An ecological momentary assessment of behavioral and experiential aspects of valued actions, well-being, and emotional distress. [PDF]
Appl Psychol Health Well BeingAbstract Although engaging in valued actions is often positively related to mental health, this relationship is not always consistent at the daily level, suggesting that how valued actions are experienced is also important. We examined three valued action aspects (extent of engagement, awareness of engaging in valued actions, and perceived effort) and ...
Sarrión P +5 more
europepmc +2 more sources
Generation of 3D reference dosimetric datasets towards adoption of model-based dose calculations for permanent implant prostate brachytherapy. [PDF]
Med PhysAbstract Purpose This work aims to create and validate a comprehensive set of test cases and 3D reference dosimetric datasets for model‐based dose calculation algorithms (MBDCAs) in permanent implant prostate brachytherapy. These test cases address the limits of the standard TG‐43 formalism towards improving dose evaluations in prostate cancer ...
Akbari F +8 more
europepmc +2 more sources
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial. [PDF]
Aging CellIn frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Olaso-Gonzalez G +13 more
europepmc +2 more sources
Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity. [PDF]
Eur J NeurosciNumerical cognition arises from conserved mechanisms linking genes, neural circuits and behaviour. Using zebrafish as a tractable model, behavioural assays, whole‐brain imaging and genetic analyses can be integrated to identify neural and molecular bases of quantity discrimination. This framework provides a platform for studying numerical cognition and
Zanon M +3 more
europepmc +2 more sources
The anxiety of influence: a review of Luis Cernuda's poetry through the myth of Narcissus
Anuario de Estudios Filológicos, 2021 The aim of this paper is to examine the presence of the story of Narcissus in the work of Luis Cernuda, allowing us to appreciate how the Sevillian author develops and treats the myth, all of this from a diachronic dimension and from the perspective of ...
Eva María Romero Rivero
doaj +1 more source
Labour Relations and Human Resources: Students’ Perceptions of Their Training in Digital Competences
International Journal of Research in E-Learning, 2022 Nowadays, the acquisition of a high level of digital competence has become a real need for professional development in any field. Future graduates in Labour Relations and Human Resources should achieve an advanced level of this skill.
Triana Arias Abelaira +1 more
doaj +1 more source
Red U, 2022 La pandemia por el virus COVID-19 ha obligado a muchos docentes universitarios a iniciarse en el uso de herramientas docentes basadas en la Web 2.0.
Antonio Chamorro Mera +3 more
doaj +1 more source
INFAD, 2021 Apostar por la inclusión educativa supone promover una educación de calidad para todo el alumnado. Las creencias y actitudes del profesorado hacia la inclusión constituyen un factor que puede influir sobre la calidad de la respuesta educativa que reciben
María del Carmen Plata Morán +3 more
doaj +1 more source