Results 11 to 20 of about 191,774 (195)
Advanced Healthcare Materials, EarlyView.Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang +11 more
wiley +1 more source
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties
Advanced Materials, EarlyView.NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang +25 more
wiley +1 more source
Advanced Science, EarlyView.Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui +17 more
wiley +1 more source
Advanced Science, EarlyView.Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia +8 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.The six autoantibodies (Sui1, p62, RalA, p53, NY‐ESO‐1 and c‐myc) positive group had poor prognosis compared to autoantibody negative group. A panel of autoantibodies against a tumor associated antigen in esophageal cancer patients had an additive effect with SCC‐Ag to detect esophageal SCC even in early stage.
Fumiaki Shiratori +16 more
wiley +1 more source
Higher education academic salaries in the UK [PDF]
, 2009 It is widely believed that higher education academic salaries are too low, and that this may lead to a ‘brain drain’ and also lower quality in higher education, as universities fail to attract the ‘brightest and the best’.
A. Vignoles +4 more
core +3 more sources
Evaluation of an Oral Health Training Program for School Nurses [PDF]
, 2005 Pediatric dental disease is a silent epidemic (Committee on Health, Education, Labor, and Pensions, 2002). Dental decay is commonly unrecognized and under-treated. Dental disease can affect children\u27s growth and development as well as their ability to
Haines-Kolostian, Kelley
core +4 more sources
Dental Student Indebtedness: Where did It Come From and Where Will It Lead? [PDF]
, 2013 Today’s dental school graduates are burdened by an ever-increasing amount of student loan debt from both their undergraduate and predoctoral educations. Although considered to be multifactorial in origin, this article explores the microeconomic theory of
Stafford, Gary L
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.Delayed initiation of adjuvant chemotherapy (AC) is associated with significantly poorer postoperative survival in patients with gastric cancer, irrespective of whether preoperative chemotherapy was administered. These findings emphasize the importance of timely AC initiation to improve long‐term outcomes in this patient population.
Masataka Shimonosono +6 more
wiley +1 more source