Results 211 to 220 of about 510,264 (294)

XPC Deficiency Activate Cisplatin‐Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1‐Mediated Ubiquitination of the p53 Protein

open access: yesAdvanced Science, EarlyView.
This study reveals that XPC regulates autophagy signaling beyond its noncanonical DNA repair role, uncovering the XPC‐p‐ATM‐KDM4A‐PHRF1 axis as a novel mechanism for autophagy modulation under DNA damage stress. It identifies PHRF1 as a novel p53 ubiquitin ligase.
Baixiong Zhao   +10 more
wiley   +1 more source

NOX2‐Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis–Osteogenesis at the Bone–Implant Interface in Diabetes

open access: yesAdvanced Science, EarlyView.
NOX2‐driven oxidative stress disrupts angiogenesis–osteogenesis coupling at the diabetic bone–implant interface. Pharmacologic inhibition and endothelial‐specific NOX2 knockout restore type‐H endothelium, suppress EndMT, and improve osseointegration.
Zimei Wu   +6 more
wiley   +1 more source

Knowledge, Attitude and Practices of Primary School Teachers Towards Oral Health in Mchinji District, Malawi. [PDF]

open access: yesClin Cosmet Investig Dent
Kafera G   +6 more
europepmc   +1 more source

Dissolution Study of Biodegradable Magnesium Silicide Thin Films for Transient Electronic Applications

open access: yesAdvanced Science, EarlyView.
Magnesium silicide (Mg2Si) is introduced as a narrow‐bandgap, biodegradable semiconductor for transient electronics. RF‐sputtered and annealed Mg2Si thin films show high intrinsic electrical conductivity and low thermal conductivity. The polycrystalline material undergoes hydrolysis in aquatic and composting environments with minimal cytotoxicity ...
Ji‐Woo Gu   +17 more
wiley   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

open access: yesAdvanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang   +12 more
wiley   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

open access: yesAdvanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou   +16 more
wiley   +1 more source

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