Results 251 to 260 of about 7,393,185 (358)

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Development and validation of an innovation competence instrument for medical mentors in China: a mixed-methods study. [PDF]

BMC Med Educ
Chen G, Wu J, Ni Q, Mao X, Wang YC, Yue JJ.   +5 more
europepmc   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science, EarlyView.
USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
wiley   +1 more source

Lessons From Reimagining Residency and the Future of Innovation in Graduate Medical Education. [PDF]

J Grad Med Educ
Andrews JS, Shea B, Santen SA, Richardson J.   +3 more
europepmc   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Evaluating Teaching Health Center Planning and Development: Unlocking and Sustaining the Full Potential of the Teaching Health Center Program. [PDF]

J Grad Med Educ
Hawes EM, Adhikari M, Rains J, Newton H, Rodefeld L, Clements D, Fraher E.   +6 more
europepmc   +1 more source

3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Advanced Science, EarlyView.
This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods, Dahnan Spurling, Sandra Sunil, Anne Marie O'Callaghan, Jack Maughan, Javier Gutierrez‐Gonzalez, Tara K. McGuire, Liam Leahy, Adrian Dervan, Valeria Nicolosi, Fergal J. O'Brien   +10 more
wiley   +1 more source

Integrating web-based and objective structured clinical examination training programs for nurses on ultrasound hip screening during neonatal and infant home visits: a case study. [PDF]

BMC Med Educ
Yoshioka-Maeda K, Matsumoto H, Honda C, Kinjo T, Aoki K, Hattori T, Okada K, Shirouchi M, Shiomi M, Hosoya N, Fujiwara K.   +10 more
europepmc   +1 more source

Sparse Nanocrystals Enable Ultra‐Low Coercivity and Remarkable Mechanical Robustness in High‐Entropy Amorphous Alloy

Advanced Science, EarlyView.
An order modulation strategy is introduced to overcome trade‐off between mechanical and magnetic properties by constructing an amorphous‐nanocrystalline transitional structure in a ferromagnetic HEA system. This enable the resultant alloys to combine an ultra‐low coercivity of 0.3 A m−1 with a remarkable mechanical toughness, thereby achieving a ...
Lichen Liu, Liliang Shao, Yan Ma, Zhilin Wen, Jing Zhou, Yuqiang Yan, Weiming Yang, Haibo Ke, Weihua Wang   +8 more
wiley   +1 more source

The Impact of Race, Education, Economic Vulnerability, and Stigma on Viral Load Detectability Among People Living with HIV in Brazil. [PDF]

HIV AIDS (Auckl)
Brandelli Costa A, Graeff Bins-Ely I, Penzato V, Vaitses Fontanari AM, Alckmin-Carvalho F, Pereira H, Welter Wendt G.   +6 more
europepmc   +1 more source