Results 61 to 70 of about 1,691,550 (319)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Evaluation of the Hemostatic Activity of Multicomponent Polymer Sponge Implants in An In Vitro Experiment

Неотложная медицинская помощь
BACKGROUND. The development of new samples of local hemostatic agents is an intensively developing area of the modern industrial biotechnology due to a high need of clinical bases for such products.
V. A. Lipatov, S. V. Lazarenko, D. A. Severinov, A. A. Denisov, O. V. Padalkina   +4 more
doaj   +1 more source

Development of an Evidence-Based, Theory-Informed National Survey of Physician Preparedness for Genomic Medicine and Preferences for Genomics Continuing Education

Frontiers in Genetics, 2020
Despite some early implementation of genomic medicine globally, there is a lack of rigorous, large-scale assessments of medical specialists' current practice and continuing education needs.
B. McClaren, Emily King, E. Crellin, C. Gaff, S. Metcalfe, A. Nisselle   +5 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Venereology at the Polyclinic: postgraduate medical education among General Practitioners in England, 1899–1914 [PDF]

, 2015
In 1899 the British Medical Journal enthusiastically announced that a new postgraduate teaching college was to open in London. The aim of the Medical Graduates’ College and Polyclinic (MGC) was to provide continuing education to general practitioners. It
Digby, Newman, Ross
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Haiti Medical Education Project: development and analysis of a competency based continuing medical education course in Haiti through distance learning

BMC Medical Education, 2016
Recent calls for reform in healthcare training emphasize using competency-based curricula and information technology-empowered learning. Continuing Medical Education programs are essential in maintaining physician accreditation.
R. Battat, Marc Jhonson, Lorne Wiseblatt, Cruff Renard, Laura Habib, Manouchka Normil, B. Remillard, T. Brewer, G. Sacajiu   +8 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploring assessment of medical students\u27 competencies in pain medicine - A review [PDF]

, 2019
Introduction: Considering the continuing high prevalence and public health burden of pain, it is critical that medical students are equipped with competencies in the field of pain medicine. Robust assessment of student expertise is integral for effective
Adillon, Adwan, Al-Rukban, Ali, Ali, Ameringer, Anderson, Antman, Argyra, Arwood, Banja, Biggs, Breivik, Briggs, Briggs, Carr, Carraccio, Case, Cohen, Corrigan, Dominick, Downing, Driessen, Eijsvogels, Emke, Epstein, Epstein, Erickson, Fabbian, Ferris, Fete, Finnerup, Fishman, Fishman, Frank, Frenk, Gatchel, Gehlhar, Ger, Gerbershagen, Gordon, Green, Gruppen, Hanna, Haq, Harden, Harendza, Harlen, Hirsh, Hoy, Hunter, Hunter, Kaki, Kennedy, Khan, Lasch, Lee, Leila, Lockyer, Loeser, Manalo, Manchikanti, Merrill, Mezei, Miller, Morley-Forster, Morris, Murinson, Nabishah, Niemi-Murola, Nimmaanrat, Oudkerk Pool, Paneduro, Pilowsky, Plymale, Portenoy, Puljak, Pöyhiä, Rainville, Reeves, Salam, Schopflocher, Schreiner, Schuwirth, Shipton, Shipton, Siddall, Silva, Sloan, Sloan, Sloan, Stevens, Strohbuecker, Symonds, Tauben, Tellier, Terry, Thomson, Turner, Twigg, van den Beuken-van Everdingen, van der Vleuten, Wass, Watt-Watson, Watt-Watson, Weiner, Weinstein, Weissman, Wijnen-Meijer, Yanni   +109 more
core   +2 more sources