Results 71 to 80 of about 20,806,161 (364)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

KEC Course: Playing Multispecies in the Anthropocene

open access: yesParse Journal, 2022
This is a course description on how to work together and develop a game with the help of norm-critical pedagogy and feminist posthumanities. The course was first proposed by Linda Paxling and is revised by the KEC Board for Course Development to fulfil ...
Krabstadt Education Center   +1 more
doaj  

Why Earth Science? [PDF]

open access: yes, 2004
This is a web version of a brochure produced by the American Geological Institute to inform people about the importance of Earth science education in K-12 schooling. Educational levels: General public, High school, Intermediate elementary, Middle school,
Michael Smith
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

On Crits and Games—and Crits as Games A Conversation between Sille Storihle and KEC

open access: yesParse Journal, 2022
A conversation between artist and educator Sille Storihle and the Krabstadt Education Center (KEC) about overlapping interests in educational models and games.
Krabstadt Education Center   +1 more
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Education in the era of competences [PDF]

open access: yesRevista Electrónica Interuniversitaria de Formación del Profesorado, 2010
The paper analyses the situation of education in Europe: after fifteen years of educational policies that put education at the service of markets, the educational concept of "competence approach" is being implemented in most European countries.
Education in the era of competences
doaj  

NH International Seminar, Spring 2019: Politics in a Globalizing World [PDF]

open access: yes, 2019
Diana OrcésProfessor and Research AnalystFebruary 7, 2019 Countering U.S. Immigration Policy in the Trump Era Lihi Ben ShitritProfessor, Political Scientist, and Women\u27s Studies ExpertMarch 5, 2019 Women and the Holy City: Women\u27s Movements and ...
Global Education Center
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

NH International Seminar, Spring 2018: Diplomacy & Innovation in a Globalizing World [PDF]

open access: yes, 2018
Devi LockwoodPoet / Touring Cyclist / StorytellerFebruary 15, 2018 1,001 Stories on Water and Climate Change Kelsey HallingDirector of Sales, ThreadZachary AngeliniEnvironmental Stewardship Manager, TimberlandMarch 27, 2018 Thread X Timberland in Haiti:
Global Education Center
core   +1 more source

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