Results 71 to 80 of about 17,225,283 (320)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Reviewers 2021

open access: yesQualitative Research in Education, 2022
Qualitative Research in Education
doaj   +1 more source

Validity and reliability of the 20-m run, horizontal leap, and four-bound tests measuring high-level mobility in neurologically impaired patients

open access: yesHong Kong Physiotherapy Journal, 2015
Background: High-level mobility (HLM) training including running forms an integral part of physical rehabilitation for neurologically impaired patients.
Marek Gorski, Master of Education (Physical Education)   +2 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Editorial

open access: yesThe Australian Journal of Indigenous Education, 2015
The challenge for any research journal today is how to continue to make the work we publish relevant, contemporary and innovative for the research groups, educational organisations, and Indigenous communities locally and globally that we serve.
The Australian Journal of Indigenous Education
doaj   +1 more source

Students And Service Staff Learning And Researching Together On A College Campus [PDF]

open access: yes, 2003
Describes the preliminary study of a service learning program at Swarthmore College that paired students and college service staff in learning partnerships and as researchers of the program.
Anderson, Diane Downer
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Cassandra’s prophecy: education, education, education [PDF]

open access: yesReproductive BioMedicine Online, 2013
This is a commentary on the personal account of Jane Everywoman. It reflects on her experiences and thoughts. The author adds context from her own work with the Progress Educational Trust, the Daisy Network Premature Menopause Support Group and the National Infertility Awareness Campaign.
openaire   +2 more sources

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