, 2001 Après la présentation d'une démarche originale de description de l'expérience humaine, la recherche analyse les dilemmes vécus par deux enseignants débutants et la manière dont ils les résolvent. Elle discute ensuite de l'intérêt d'une telle étude de cas dans les plans de formation initiale.
Ria, Luc +3 more
openaire +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Commission 46: Astronomy Education and Development (Enseignement De L’astronomie) [PDF]
Transactions of the International Astronomical Union, 2007 openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Sozialwissenschaften, Geschichte und Rechtswissenschaft [PDF]
, 2010 Hammerstein, Nokter, Heirbaut, Dirk
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
"In-the-moment" feedback: a novel app for clinical teaching evaluations. [PDF]
Can Med Educ JHalani S +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Implementation of a Multiplex PCR Amplification System Combined With Next-Generation Genome Sequencing to Decipher the Circulation of Human Coronavirus 229E Lineages in Southern France. [PDF]
J Med VirolHikmat H +9 more
europepmc +1 more source
The structure of secondary education in the Six. Trade unions in Britain and the Common Market. Energy in the EEC (II). Farming in the Common Market (ll). European Studies Teachers' Series 6 [PDF]
, 1969 core