Results 191 to 200 of about 5,004,160 (315)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Leprosy stigma in the healthcare setting: Lived experiences of persons affected by leprosy in Niger. [PDF]

PLoS Negl Trop Dis
Alio AP, Malam Mamane Sani I, Abdou Y, Gado M, Harouna I, Celiktemur B.   +5 more
europepmc   +1 more source

Colloque RECHERCHE PARTENARIALE : EDUCATION, ENSEIGNEMENT ET FORMATION, Jeudi 9 mars 2023, 13h00, CNRS, Paris

Les carnets de SFERE-Provence, 2023
openaire   +2 more sources

Education of the children of migrant workers: Community directive. Information Memo P-54/81, July 1981 [PDF]

, 1981

core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Territorial and gender-linked risk factors for Buruli ulcer in Southern Benin: A case-control study using geographic and behavioral surveying. [PDF]

PLoS Negl Trop Dis
Johnson H, Boccarossa A, Anagonou E, Brou T, Catraye P, Fleuret S, Marion E, Eveillard M.   +7 more
europepmc   +1 more source

Rencontres annuelles : Philosophie, Education, Enseignement, jeudi 17 octobre 2013, Toulouse

Le Carnet du Sophiapol, 2013
openaire   +1 more source

La professionnalisation de l’enseignement chez les Anglo-Québécois [PDF]

, 1993
Rebuffot, Jacques J.
core   +1 more source

« Perception de la fréquence d'apparition des comportements perturbateurs par des stagiaires en enseignement de l'éducation physique et à la santé (EPS) »

, 2013
J. Desbiens, Sèverine Lanoue, Sylvain Turcotte, Jean-Sébastien Tourigny, Carlo Spallanzani   +4 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source