Results 141 to 150 of about 14,139,318 (310)

Using collaborative CoRe design in chemistry education to promote effective partnerships between associate and student teachers [PDF]

open access: yes, 2011
This article is a follow-up to my paper published in 2010 (Hume, 2010). In that paper I reported on the use of Content Representations (CoRes) in a chemistry education course to give student teachers insights into the professional knowledge of ...
Hume, Anne Christine
core   +1 more source

Turning educational content into open content: a workshop [PDF]

open access: yes, 2008
The POCKET project is building on the infrastructure provided by the Open University’s OpenLearn open educational repository. POCKET, the Project on Open Content for Knowledge Exposition and Teaching, is led by the University of Derby and partnered by The Open University, the University of Exeter and the University of Bolton.
McAndrew, Patrick   +3 more
openaire  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Guide to Special Education.

open access: yes, 1998
"July 1998." Includes bibliographical references."This Guide to Special Education includes information helpful to parents, Education Advocates, self-advocates, educators, administrators, other professionals and school staff.
Kansas. State Department of Education. Student Support Services.
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Values, ethics and empowering the self through cooperative education [PDF]

open access: yes, 2011
Following the recent global financial crisis and the collapse of major organisations such as Lehman Brothers, and the earlier corporate failings of Enron and HIH, there has been a shift of focus towards the role of ethics education in the formation of ...
Campbell, Matthew, Zegwaard, Karsten E.
core  

Exploring antenatal education content for couples in Blantyre, Malawi. [PDF]

open access: yesBMC Pregnancy Childbirth, 2018
Chikalipo MC, Chirwa EM, Muula AS.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

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