Results 71 to 80 of about 1,588,032 (327)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in EducationBackgroundIn today's digital age, online education helps eliminate certain barriers faced by traditional education, however, it also presents challenges, including issues related to the culture of conduct among high school students in their relationships
Bui Thanh Thuy +5 more
doaj +1 more source
Education for sustainable development: new opportunities with the rce network
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2019 The goals of sustainable development can not be achieved only through technological innovation, policy decisions and financial support. Education for sustainable development (ESD) makes it possible to deal constructively and creatively with current and ...
Mariya V. Yurina +2 more
doaj +1 more source
A UK indicator of education for sustainable development [PDF]
, 2012 Report references UK Government publication 'Securing the Future'.Report on workshops consulting members of the education community on their preferred approach to the indicator announced in the UK strategy for sustainable development, 'Securing the ...
Huckle, John +1 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Land, 2021 Spain is one of the most popular tourism destinations in the world, and one of the top ten countries in terms of tourism contribution to its economy.
Libertad Moreno-Luna +3 more
doaj +1 more source
Identification of levels of sustainable consciousness of teachers in training through an e-portfolio [PDF]
, 2018 The contents of Education for Sustainable Development should be included in teachers’ initial and advanced training programs. A sustainable consciousness is one of the main foundations for determining the key competences for sustainability.
Colás Bravo, María Pilar +2 more
core +1 more source
Journal of Teacher Education for Sustainability, 2021 Promoting Education for Sustainable Development (ESD) in higher education implies an improvement and quality in the exercise of responsible citizenship, being the key in the training of future teachers as the main agent of change and transition towards ...
M. C. Pegalajar-Palomino +2 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source