Results 41 to 50 of about 7,245,178 (315)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Education and general culture

Revista MENDIVE, 2004
This article explains the term of integral general culture by means of an analysis of its appearance in speeches and interviews of the Commandant in Chief, Fidel Castro Ruz, and other leaders of the Revolution, as well as the interaction of education ...
Yadyra Piñera Concepción, Idalberto Rodríguez Poo   +1 more
doaj  

Liberal And General Studies In Further Education: Voices From The ‘Chalk Face’ [PDF]

, 2014
This paper presents initial findings from research investigating an important but largely neglected facet of the history of Further Education (FE) – the Liberal Studies and General Studies (LS/GS) movement.
Hopkins, Mike, Perry, Liz, Simmons, Robin, Stafford, Roy, Waugh, Colin   +4 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Sustainability Education and Critical Thinking Integration in General Education

International Journal of Current Educational Studies
Education and critical thinking are integral in the achievement of Sustainable Development Goals (SDGs). Thus, this study aims to examine the extent of integration of sustainability education (SE) and critical thinking (CT) in General Education (GE ...
Joseph Jintalan, Rodrigo A. Litao
doaj   +1 more source

Development of type 2 diabetes mellitus quality indicators in general practice by a modified Delphi method in Beijing, China

BMC Family Practice, 2020
Background The service capacity of primary care has improved in China. General practice also takes growing responsibility in the management of type 2 diabetes mellitus, but there are concerns about the paucity of evidence of the quality of care delivered.
Guanghui Jin, Yun Wei, Yanli Liu, Feiyue Wang, Meirong Wang, Yali Zhao, Juan Du, Shuqi Cui, Xiaoqin Lu   +8 more
doaj   +1 more source

Chichester College of Arts, Science and Technology (FEFC inspection report; 72/95 and 43/99) [PDF]

, 1999
Comprises two Further Education Funding Council (FEFC) inspection reports for the periods 1994-95 (72/95), and 1998-99 (43/99). The FEFC has a legal duty to make sure further education in England is properly assessed.

core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Why general education?: Peters, Hirst and history [PDF]

, 2009
Richard Peters argued for a general education based largely on the study of truth-seeking subjects for its own sake. His arguments have long been acknowledged as problematic. There are also difficulties with Paul Hirst's arguments for a liberal education,
Adamson, Bain, Board of Education, Brown, Comenius, Comenius, Doddridge, Dury, Gardner, Goodson, Grafton, Graves, Harvard Report, Hirst, Hirst, Hotson, Hotson, Hotson, Mercer, Newman, Norwood Report, Peters, Phenix, Phenix, Reid, Sell, Tawney, Trevor-Roper, Webster, White, White, White   +31 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source