Results 41 to 50 of about 13,361,051 (298)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Character Values In General Education At University
Jurnal Pendidikan Ilmu Sosial, 2023 The research objective focuses on examining the character values contained in the Compulsory Curriculum Subjects or Mata Kuliah Wajib Kurikulum (MKWK). Content analysis and Focus Group Discussions (FGD) attended by education experts.
Mupid Hidayat +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Revista MENDIVE, 2004 This article explains the term of integral general culture by means of an analysis of its appearance in speeches and interviews of the Commandant in Chief, Fidel Castro Ruz, and other leaders of the Revolution, as well as the interaction of education ...
Yadyra Piñera Concepción +1 more
doaj
Perspectives on blended learning through the on-line platform, LabLessons, for Chemistry
Journal of Technology and Science Education, 2018 The effectiveness of blended learning was evaluated through the integration of an online chemistry platform, LabLessons. Two modules, Titration and Formation of Hydrogen, were designed by college mentors alongside classroom chemistry teachers to engage ...
Teeba Jihad +6 more
doaj +1 more source
Theory, a lost character? As presented in general practice education research papers
Medical Education, 2019 The use of theory in research is reflected in its presence in research writing. Theory is often an ineffective presence in medical education research papers.
James Brown +5 more
semanticscholar +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Vocational vs. General Education and Employment Over the Life-Cycle: New Evidence from PIAAC
Social Science Research Network, 2016 It has been argued that vocational education facilitates the school-to-work transition but reduces later adaptability to changing environments. Using the recent international PIAAC data, we confirm such a trade-off over the life-cycle in a difference-in ...
Franziska Hampf, Ludger Woessmann
semanticscholar +1 more source