Results 61 to 70 of about 7,245,178 (315)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An Initiative to Develop OER-Based General Education Courses in Higher Education [PDF]
, 2023 Shanta Goswami Varma, Xinyue Ren
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Digital games and art-education: general meanings
Revista Gearte, 2019 This article intends to present, briefly, the pedagogical possibilities in the use of digital games as a tool in teaching art. Relating the current context of video games, this is the discussion of their artistic character as an analogy to facilitate the
Sara Raquel Andrade Silva
doaj +1 more source
Mapping Twenty-First-Century General Education Based upon A Convergence Science －Humanistic Conversion of Big History [PDF]
, 2020 Hye Jeong Park
openalex +1 more source
Chippenham College (FEFC inspection report; 27/95 and 20/98) [PDF]
, 1998 Comprises two Further Education Funding Council (FEFC) inspection reports for the periods 1994-95 (27/95), and 1997-98 (20/98). The FEFC has a legal duty to make sure further education in England is properly assessed.
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
General Education and Museum Education: Between Singularity and Plurality
Revista Complutense de Educación, 2006 The article examines the relationship between general and museum education, and between the various discipline and museum educations. The term “education” is quite frequent in the daily use and –as we know– in its broader meaning it suggest the teaching ...
Antonella Nuzzaci
doaj
General or Specialised Education? Or Maybe Both…
Paedagogia Christiana, 2012 Two trends in thinking: a theoretical and a practical one, so evident in differences between Platonic and Aristotelian thinking, have forever remained in human culture and in education, which is a tool for preservation and transmission of culture.
Jarosław Michalski
doaj +1 more source