Results 61 to 70 of about 12,319,131 (335)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Is Education Associated With Improvements in General Cognitive Ability, or in Specific Skills?
Developmental Psychology, 2015 Previous research has indicated that education influences cognitive development, but it is unclear what, precisely, is being improved. Here, we tested whether education is associated with cognitive test score improvements via domain-general effects on ...
Stuart J. Ritchie +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
On the New General Psychology of Education
Вопросы образования, 2014 This is an analysis of general psychological education for future teachers in the context of the need to implement the second generation Federal State Learning Standard of General Education.
Viktor Guruzhapov
doaj +1 more source
Educating the Digital Generation [PDF]
Nordic Journal of Digital Literacy, 2010 The concept of a digital generation has been dominating the public discourse on the role of digital media in young people’s lives. Issues concerning a digital generation is closely linked to questions about how we develop an education system that is able to face the challenges of the 21st Century.
openaire +2 more sources
Artificial General Intelligence (AGI) for Education
arXiv.org, 2023 Ehsan Latif +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
General Education and Museum Education: Between Singularity and Plurality
Revista Complutense de Educación, 2006 The article examines the relationship between general and museum education, and between the various discipline and museum educations. The term “education” is quite frequent in the daily use and –as we know– in its broader meaning it suggest the teaching ...
Antonella Nuzzaci
doaj