Results 81 to 90 of about 7,245,178 (315)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Bibliometrics on General Practitioner Training Domestically and Internationally from 2013 to 2023 [PDF]
Zhongguo quanke yixueBackground The training and development of general practitioners has always been the focus of the medical community, and there are also significant differences in the training models and methods of general practitioners in various countries.
TIAN Tian, ZHANG Fei, ZHANG Xuan, LI Minglin, WANG Jiahe
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Открытое образование (Москва), 2019 The goal of this study is to transmit the project results contributing to ensuring the education system effective management by improving the education quality, to achieve the continuity of preschool and educational organizations educational programs ...
E. A. Gavrilova, N. A. Bulaeva
doaj +1 more source
Vocational and technical education in Peru [PDF]
The relative costs of and returns to VTE (Vocational and Technical Education) and general education in Peru are investigated here. The paper is composed as follows.
Bellew, Rosemary, Moock, Peter
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The demographic challenge facing Scottish higher education institutions : a computable general equilibrium analysis [PDF]
, 2009 Higher Education Institutions (HEIs) are generally regarded as important actors in regional economic development. A large literature exists on their demand side impacts as employers and as purchasers of intermediate inputs and, more recently, work has ...
Hermannsson, Kristinn +3 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Gifted Girls’ Learning Experience in General Education
Acta Paedagogica Vilnensia, 2019 The Munich Dynamic Ability-Achievement Model during the school period emphasizes the increasing impact of the school environment on the transformation of the ability (potential) of exceptional achievement, making it an integral part of the development of
Evelina Undro, Sigita Girdzijauskienė
doaj +1 more source
30th George Swift Lecture: generalism in undergraduate medical education — what's next? [PDF]
, 2012 Tony Kendrick
openalex +1 more source