Results 141 to 150 of about 2,761,226 (280)
The Korean case study : past experience and new trends in training policies [PDF]
Korea's skills development strategy has been highlighted as one of the key driving forces of the country's economic development. This paper examines the main features and evolution of this strategy from the 1960s to the present.
Ra, Young-Sun, Shim, Kyung Woo
core
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source
An Examination of State and Federal Opioid Analgesic and Continuing Education Policies: 2016-2018. [PDF]
J Pain Res, 2020 Duensing K +6 more
europepmc +1 more source
The politics, policies and progress of basic education in Sri Lanka [PDF]
, 2010 Sri Lanka is hailed internationally for her achievements in literacy, educational enrolment and equality of educational opportunity. However, progress has not been straightforward due to the complex interactions between politics, policy formulation, and ...
Little, Angela W
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Advanced Science, EarlyView.ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao +14 more
wiley +1 more source
Increasing the Economic Development Benefits of Higher Education in Michigan [PDF]
This paper considers how a state such as Michigan can increase the economic development benefits of higher education. Research evidence suggests that higher education increases local economic development principally by increasing the quality of the local
Timothy J. Bartik
core +1 more source
Expanding Access and Increasing Student Learning in Post-Primary Education in Developing Countries: A Review of the Evidence [PDF]
, 2013 Effective, evidence-based policies on post-primary education are of vital importance as many developing countries start to the see a bulge in secondary and postsecondary enrollment, the product of the achievement of near-universal access to primary ...
Abhijit Banerjee +3 more
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All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
Advanced Science, EarlyView.Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi +15 more
wiley +1 more source